Alcohol and folate intake and breast cancer risk in the WHI Observational Study.
Alcohol and folate intake and breast cancer risk in the WHI Observational Study.
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DOI：
10.1007/s10549-008-0167-2
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发表时间：
2009-08
影响因子：
3.8
通讯作者：
Chetty, V. K.
中科院分区：
文献类型：
--
作者：
Duffy, Christine M.;Assaf, Annlouise;Cyr, Michele;Burkholder, Gary;Coccio, Elizabeth;Rohan, Tom;McTiernan, Anne;Paskett, Electra;Lane, Dorothy;Chetty, V. K.
酒精会增加患乳腺癌的风险。流行病学研究表明，叶酸可能会改变这种关系。在妇女健康倡议-观察性研究(WHI-OS)中检查乳腺癌、酒精和叶酸之间的关系。88,530名50-79岁的绝经后妇女在1993年10月至1998年12月期间完成了基线调查问卷，这些问卷涉及酒精和叶酸摄入量与乳腺癌风险因素。COX比例风险分析检验了自我报告的基线酒精和叶酸摄入量与乳腺癌发病的关系。1783例乳腺癌病例发生在5年内。饮酒与乳腺癌风险增加相关(RR=1.005，95%CI 1.001-1.009)。风险随着饮酒的增加而增加(5g/d以下，调整后HR=1.10，95%CI 0.96-1.32；>；5-15g/d HR=1.14，95%CI 0.99-1.31；>；15g/d HR=1.13，95%CI 0.96-1.32)。在我们调整后的模型中，我们发现酒精和叶酸之间没有显著的相互作用。我们发现没有证据表明叶酸可以减轻酒精对绝经后女性乳腺癌风险的影响。我们的结果可能是由于对叶酸摄入量的错误分类或相对较短的随访期。
Alcohol increases breast cancer risk. Epidemiological studies suggest folate may modify this relationship. To examine the relationship among breast cancer, alcohol and folate in the Women’s Health Initiative-Observational Study (WHI-OS). 88,530 postmenopausal women 50–79 years completed baseline questionnaires between October 1993 and December 1998, which addressed alcohol and folate intake and breast cancer risk factors. Cox proportional hazards analysis examined the relationship between self-reported baseline alcohol and folate intake and incident breast cancer. 1,783 breast cancer cases occurred over 5 years. Alcohol was associated with increased risk of breast cancer (RR = 1.005, 95%CI 1.001–1.009). Risk increased with consumption of alcohol (up to 5 g/d, adjusted HR = 1.10, 95%CI 0.96–1.32; >5–15 g/d HR = 1.14, 95%CI 0.99–1.31; and >15 g/d HR = 1.13 95%CI 0.96–1.32). We found no significant interaction between alcohol and folate in our adjusted model. We found no evidence for folate attenuating alcohol’s effect on breast cancer risk in postmenopausal women. Our results may be due to misclassification of folate intake or the relatively short follow-up period.
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