Oncogenic Human Papillomaviruses & Prostate Cancer Risk

前列腺癌是男性最常见的癌症原因，但很少有人发现这种疾病的危险因素。先前的一些研究表明，性行为和相关的性传播媒介暴露会增加前列腺癌的风险，特别是性伴侣数量、首次性交年龄、性行为频率、淋病和梅毒病史、梅毒的血清学证据和致癌亚型的人乳头瘤病毒(HPV)与前列腺癌的风险相关，但结果尚未得到证实。在最近一项关于65岁以下男性前列腺癌风险因素的研究中，我们发现随着女性性伴数量的增加，风险显著增加(趋势P&lt；0.001)，我们假设这与先前接触i-IPV-16或-18有关。为了验证这一假设，我们提出了一项基于人群的病例对照研究，将分析1993-1996年间诊断的组织学确诊的前列腺癌病例(n=648)和西雅图-普吉特湾SEER登记处确定的存储血清，以及没有前列腺癌病史和年龄与癌症病例匹配频率的对照男性(n-571)的存储血清。BPV-16和BPV-18的检测将采用病毒样颗粒EL ISA血清学方法。有关前列腺癌已知和可疑风险因素的详细数据将通过面对面采访获得。非条件Logistic回归将用于估计与HPV-16/-18感染相关的相对风险，控制潜在的混杂因素。前列腺癌病例的临床数据将被用来评估是否与HPV的关联根据疾病侵袭性的不同而不同。这项研究的结果将提供关于这些致癌HPV亚型是否在前列腺癌病因中发挥作用的见解。如果存在关联，结果将具有重要的公共卫生影响，因为接触和疾病都很常见。

Prostate cancer is the most frequent cause of cancer in men, yet few risk factors for this disease have been identified. Some prior studies suggest that sexual behavior and associated exposure to sexually transmitted agents enhance risk In particular, number of sexual partners, age at first intercourse, sexual frequency, history of gonorrhea and syphilis, and serologic evidence of syphilis and oncogenic subtypes of human papillomavirus (HPV) have been associated with risk of prostate cancer, but results have not been confirmed. In a recent study of risk factors for prostate cancer in men under age 65 years, we found a significant increase in risk with increasing number of female sexual partners (trend p <0.001), which we hypothesize is related to prior exposure to I-IPV-16 or -18. To test this hypothesis, we propose a population-based case-control study that will analyze stored serum from histologically confirmed prostate cancer cases (n=648) diagnosed during 1993-1996 and ascertained by the Seattle-Puget Sound SEER registry and from control men (n--571) without a history of prostate cancer and frequency matched on age to cancer cases. Virus-like particle ELISA serologic assays will be used to detect BPV-16 and -18. Detailed data on known and suspected risk factors for prostate cancer will be available from in-person interviews. Unconditional logistic regression will be used to estimate relative risks associated with HPV- 16/-18 infection, controlling for potential confounding factors. Clinical data on prostate cancer cases will be utilized to assess whether associations with HPV differ according to disease aggressiveness. Results from this study will provide insight on whether or not these oncogenic HPV subtypes play a role in prostate cancer etiology. If there is an association, the results will have important public health implications since both the exposure and the disease are common.