COGNITIVE BEHAVIORAL TREATMENT OF MEMORY PROBLEMS

记忆问题的认知行为治疗

基本信息

批准号：
6514918
负责人：
ROBERT J FERGUSON
金额：
$ 7.95万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-01 至 2004-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6514918
关键词：
antineoplastics attention behavioral /social science research tag breast neoplasms cancer rehabilitation mental health service cognitive behavior therapy drug adverse effect female functional ability human subject human therapy evaluation long term survivor memory disorders neuropsychological tests patient oriented research psychological aspect of cancer quality of life women's health

项目摘要

DESCRIPTION: (Applicant's Description) Cognitive deficits associated with cancer treatment can have a dramatic effect on patients' quality of life and have been recognized as a problem by the President's Cancer Panel (1999) and the National Coalition for Cancer Survivorship for those living with cancer (Ferrell Hassey & Dow, 1997). Increasing evidence suggests that standard dose, systemic chemotherapy can produce memory and concentration deficits in adult 5-year cancer survivors (Ahles, 1999). While more research on the cognitive effects of chemotherapy is needed, mounting evidence suggests strongly that development of interventions to improve cognitive functioning following chemotherapy is important. The present application proposes pilot testing a brief cognitive-behavioral treatment program (4 visits with 3 phone contacts) designed to assist breast cancer survivors in compensating for cognitive impairment associated with systemic chemotherapy. The principal long-term objective of this work is to examine the treatment program's feasibility to be carried out in clinical oncology settings at this pilot-phase of treatment development and examine its preliminary effectiveness in a small sample of cancer survivors. Results will aid planning and carry-through of a randomized controlled trial of efficacy in future investigation. Specific aims of the present project are: 1. To evaluate the feasibility of a brief cognitive-behavioral treatment program designed specifically for rehabilitation of cognitive deficits resulting from systemic chemotherapy. Breast cancer survivors will be the target population. 2. Pilot-test the effectiveness of the brief cognitive-behavioral treatment as a first-phase of treatment development (one-group, repeated measures design). 3. Quantify the proportion of treatment participants who achieve clinically significant improvement using statistical methods to determine clinically significant outcomes in behavioral research (Jacobson, Roberts, Berns, & McGlinchey, 1999). Clinically significant change will be defined as exceeding the reliable change index (RCI) in pre- to post-test scoring on self-report measures of cognitive functioning and quality of life measures. 4. Evaluate participant satisfaction with treatment. Thirty-three breast cancer survivors (5 years after disease remission) with attention and memory deficits will enroll in the pilot treatment. A single-group, 3 (time: pre-treatment, post-treatment, 2-month follow-up) X 1 (treatment group) repeated-measures, multivariate analysis of variance (MANOVA) design will be used to evaluate effects of treatment on three dependent measures: 1) standardized self-report measure of cognitive function; 2) a global neuropsychological test performance score; and 3) a self-report measure of survivor quality of life. Participant satisfaction and adherence to behavioral and cognitive homework tasks will also be assessed by quantifying these variables with descriptive statistics. Implications for future study are discussed.

描述：（申请人的描述）与癌症治疗相关的认知缺陷可能会产生巨大的影响关于患者的生活质量，并被认为是一个问题总统的癌症小组（1999）和全国癌症联盟为患有癌症的人而生存（Ferrell Hassey＆Dow，1997）。越来越多的证据表明，标准剂量，全身化疗可以在成人5年癌症幸存者中产生记忆和浓度缺陷（Ahles，1999）。虽然对化学疗法的认知作用的更多研究是需要的是，越来越多的证据表明，干预措施的发展改善化学疗法后的认知功能很重要。这目前的申请提出了试点测试简短的认知行为治疗计划（4次访问3个电话联系人），旨在帮助乳房癌症幸存者补偿与全身化疗。这项工作的主要长期目标是检查治疗计划在临床上执行的可行性这种治疗开发试验性的肿瘤学环境并检查其在一小部分癌症幸存者样本中的初步有效性。结果将援助计划和随机对照试验的疗效试验未来的调查。本项目的具体目的是： 1。评估短暂认知行为治疗的可行性专为康复认知缺陷而设计的计划由全身化疗产生。乳腺癌幸存者将是目标人群。 2。试点测试短暂认知行为治疗的有效性治疗发展的第一阶段（一组，重复测量设计）。 3。量化临床实现的治疗参与者的比例使用统计方法的显着改善来确定临床行为研究的重大结果（雅各布森，罗伯茨，伯恩斯，＆ McGlinchey，1999）。临床上显着的变化将定义为超过在自我报告的测试前和测试前的可靠变更指数（RCI）认知功能和生活质量措施的度量。 4。评估参与者对治疗的满意度。三十三个乳腺癌幸存者（疾病缓解后5年）注意力和记忆缺陷将参加试验治疗。一个单组，3（时间：预处理，治疗后，2个月的随访）x 1 （治疗组）重复测量，方差多变量分析（Manova）设计将用于评估治疗对三个的影响依赖度量：1）认知功能的标准化自我报告量度； 2）全球神经心理测试表现评分； 3）自我报告衡量幸存者生活质量。参与者的满意和遵守行为和认知作业任务也将通过量化来评估这些具有描述性统计的变量。对未来研究的影响是讨论。