Tuned Iridium Catalysts to Deliver an Array of Synthetic Efficiency and Selectivity

这项计划将建立在科尔最近在铱催化领域的记录的基础上，通过调整配体修饰来扩大可用的催化剂种类的范围，以制备有机金属化学和理论化学方法的跨学科组合为信息和指导。新出现的基于铱的新物种将专门设计用于有机合成中的一系列重要转变，并与制药业直接相关。这些将包括异构化过程、C-N和C-O键形成反应，以及温和和容易获得的不对称还原方法。EPSRC的主要研究领域包括：催化、化学反应动力学和机理、合成有机化学。

This programme will build on Kerr's recent track record in the area of iridium catalysis by expanding the range of available catalyst species through tuned ligand modification, informed and guided by the interdisciplinary combination of preparative organometallic chemistry and theoretical chemistry methods. The emerging new iridium-based species will be specifically designed for application in a portfolio of important transformations in organic synthesis and of direct relevance to the pharmaceutical industry. These will include isomerisation processes, C-N and C-O bond forming reactions, and mild and accessible asymmetric reduction methods. The main EPSRC Research Areas addressed are: Catalysis, Chemical Reaction Dynamics and Mechanism, and Synthetic Organic Chemistry.