Drug Reduction Intervention for Needle Exchange Clients

针交换客户的药物减少干预

• 批准号: 6523388
• 负责人: ARUNA GOGINENI
• 金额: $ 39.25万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6523388
• 关键词: HIV infections; adult human (21+); behavior therapy; clinical research; cost effectiveness; disease /disorder proneness /risk; drug abuse therapy; human subject; human therapy evaluation; injection /infusion; interview; longitudinal human study; motivation; needle sharing; outcomes research; placebos; substance abuse related behavior

DESCRIPTION: (Applicant's Abstract) Injection drug users are at risk for a variety of problems such as HIV infection, hepatitis B and C, endocarditis, trauma, legal and work difficulties and family dysfunction. The objective of this research is to investigate ways to effectively reduce drug use among needle exchange program users, whose attendance at such services may signal the beginnings of risk reduction and a desire to escape drug use. In the past two decades brief interventions have proven to be promising in reducing substance abuse in a variety of settings. Recent developments in treatments for substance abuse underscore the primacy of utilizing motivation-based approaches. However, few studies have examined the likelihood that using a brief motivation based intervention with drug users enrolled in needle exchange programs may improve drug use outcomes. Intensifying brief intervention by adding a booster session might further enhance efficacy. The long-term objective of this programmatic body of treatment outcome research is to provide effective brief interventions for adult substance abusers. The specific aims of this proposal are to investigate the extent to which a Motivational Interview with a booster session is effective in reducing drug use among injection drug users enrolled in needle exchange programs as compared to an Attention Placebo Control (AQ condition in a 2-group design. Patients will be followed at 1-and 6 months after the baseline intervention, with self-reports confirmed by urine screens and reports of family or friends. Primary outcome variables include total number of drug use days and number of days in treatment. It is hypothesized that groups receiving MI will show lower levels of drug using days and more days of substance abuse treatment and that 2) the relationship between MI and the outcome variables will vary as a function of the patient's degree of readiness to change. This study will extend previous research by evaluating the use of MI with individuals who are needle exchange participants. The development of effective interventions for a population with poor linkage to primary care, an enormous burden of illness, and high HIV transmission risk should reduce the chronicity of drug use and enhance days in drug treatment.

描述：（申请人摘要） 注射吸毒者面临多种问题的风险，例如艾滋病毒 感染、乙型和丙型肝炎、心内膜炎、创伤、法律和工作困难 以及家庭功能失调。本研究的目的是探讨方法 有效减少针具交换计划使用者的药物使用，其 参加此类服务可能标志着风险降低的开始和 渴望逃避吸毒。在过去的二十年里，短暂的干预已经 事实证明，它在减少各种环境中的药物滥用方面很有希望。 药物滥用治疗的最新进展强调了药物滥用治疗的首要地位 利用基于动机的方法。然而，很少有研究考察 对吸毒者进行基于动机的简短干预的可能性 参加针头交换计划可​​能会改善吸毒结果。 通过增加强化课程来强化短暂干预可能会进一步 增强功效。 该治疗结果研究的纲领性机构的长期目标 的目的是为成年药物滥用者提供有效的简短干预措施。这 该提案的具体目的是调查 励志访谈和加强会议可有效减少吸毒 参加针头交换计划的注射吸毒者中 注意安慰剂对照（两组设计中的 AQ 状况。患者将 基线干预后 1 个月和 6 个月进行随访， 通过尿液筛查确认的自我报告以及家人或朋友的报告。 主要结果变量包括吸毒总天数和吸毒次数 治疗天数。据推测，接受 MI 的群体的表现会较低 吸毒天数和药物滥用治疗天数的水平 2）MI和结果变量之间的关系将随着 患者的功能变化的准备程度。 本研究将通过评估 MI 的使用来扩展之前的研究 针头交换参与者的个人。发展有效的 对与初级保健联系较差的人群进行干预，需要付出巨大的努力 疾病负担和高艾滋病毒传播风险应减少慢性病 减少药物使用并延长药物治疗天数。