Bioengineering non-sugar modifications of saponins (OSBOURN_J17UNIL)

皂苷的生物工程非糖修饰（OSBOURN_J17UNIL）

• 批准号: 1957895
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1957895
• 关键词: Bioengineering; non; sugar; modifications; saponins

Saponins (glycosylated triterpenes) are one of the most numerous and diverse groups of plant natural products. They are complex molecules that are, for the most part, beyond the reach of chemical synthesis. These compounds have a wide range of industrial applications, including as surfactants for use in soaps and other home and personal care products. A considerable amount is now known about the enzymes that synthesise and modify triterpene scaffolds. This project exploits an innovative synthetic biology approach for easy and quick production of known and new-to-nature triterpenes using a transient plant expression system. The goal is to engineer triterpenes with optimised physical properties and performance for use in home and personal care products.

皂苷(糖基化三萜)是数量最多、种类最多的植物天然产物之一。它们是复杂的分子，在很大程度上超出了化学合成的范围。这些化合物具有广泛的工业应用，包括用作肥皂和其他家用和个人护理产品的表面活性剂。现在人们已经知道了相当多关于合成和修饰三萜支架的酶。该项目利用一种创新的合成生物学方法，利用瞬时植物表达系统，轻松、快速地生产已知和新的三萜。我们的目标是设计出具有最佳物理性能和性能的三萜类化合物，用于家用和个人护理产品。