OHSU-NIDDK Biotechnology Center

OHSU-NIDDK 生物技术中心

• 批准号: 6517843
• 负责人: RON G ROSENFELD
• 金额: $ 47.12万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-25 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6517843
• 关键词: biomedical resource; biotechnology; data management; diabetes mellitus; gene expression; genetic regulation; genome; growth factor; informatics; microarray technology; obesity; statistics /biometry; technology /technique development; training

The expansion of information about the structure and sequence of complex genomes has provided a novel opportunity to apply the study of gene regulation to physiological and pathophysiological problems on a larger scale than previously feasible. Oregon Health Sciences University has established a microarray-based gene profiling facility in order to take advantage of this new information generated by the Human and Mouse Genome Projects and to apply it to basic, translational, and clinical investigation. The major goal of this application is to develop this resource as a central component of a campus-wide expansion of modern biomedical research facilities. Three specific aims are proposed to achieve the goal of establishing a NIDDK Biotechnology Center: 1. To enhance and expand our gene-profiling facility through the following steps: (a) improving the resources devoted to the printing and processing of cDNA microarrays; (b) enhancing computational capabilities for analyzing experimental results; and (c) developing and refining other approaches to the genome-based analysis of complex physiological and pathophysiological questions. 2. To provide educational leadership for the application of microarray- based gene profiling and other methodologies to biomedical research on campus, including the development of didactic training programs and tools for biostatistics and bioinformatics. 3. To support the most meritorious scientific projects of NIDDK-funded investigators in the application of gene profiling and other methods to research in the areas of obesity and diabetes, growth factor action, control of gene expression, and disease models. This application represents a request for support from the NIDDK to enhance the capabilities of, as well as access to, a functioning facility, rather than for t establishment of a new facility. We are, therefore, in an ideal position to immediately support scientists on ca us in their application of this technology, and to rapidly extend this support to other qualified investigators whose research is relevant to the Institute's mission.

关于复杂基因组的结构和序列的信息的扩展提供了一个新的机会，可以比以前更大规模地将基因调控研究应用于生理和病理生理问题。俄勒冈健康科学大学建立了基于微阵列的基因分析设施，以便利用人类和小鼠基因组计划产生的新信息并将其应用于基础、转化和临床研究。该应用程序的主要目标是开发该资源，作为现代生物医学研究设施在校园范围内扩展的核心组成部分。为实现建立 NIDDK 生物技术中心的目标，提出了三个具体目标： 1. 通过以下步骤加强和扩大我们的基因分析设施： (a) 改善用于 cDNA 微阵列打印和处理的资源； (b) 增强分析实验结果的计算能力； (c) 开发和完善对复杂生理和病理生理问题进行基于基因组分析的其他方法。 2. 为基于微阵列的基因分析和其他方法在校园生物医学研究中的应用提供教育领导，包括开发生物统计学和生物信息学的教学培训计划和工具。 3. 支持NIDDK资助的研究人员在肥胖和糖尿病、生长因子作用、基因表达控制和疾病模型等领域应用基因分析和其他方法进行研究方面最有贡献的科学项目。该申请代表对 NIDDK 的支持请求，以增强功能设施的能力以及对功能设施的访问，而不是建立新设施。因此，我们处于理想的位置，可以立即支持科学家应用这项技术，并迅速将这种支持扩展到其他合格的研究人员，他们的研究与研究所的使命相关。