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STRUCTURAL AND FUNCTIONAL LIGAND-BINDING FEATURES OF USP

STRUCTURAL AND FUNCTIONAL LIGAND-BINDING FEATURES OF USP
USP 的结构和功能配体结合特征
批准号：
6520108
负责人：
GRACE M JONES
金额：
$26.41万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-05-01 至 2005-04-30
来源：
https://reporter.nih.gov/project-details/6520108
关键词：
Drosophilidae alkyltransferase conformation ecdysone gel mobility shift assay gene mutation human tissue juvenile hormones ligands point mutation protein binding protein protein interaction protein structure function steroid hormone receptor transcription factor yeast two hybrid system

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英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): The long term objective of this research is to determine the mechanisms by which the invertebrate nuclear receptor, ultraspiracle, transduces the regulatory signals of its endogenous ligands(s) into pathways for transcriptional activation. The proposed research builds upon their recent studies that have demonstrated that two natural dipteran epoxymethylfarnesoates bind with specificity to ultraspiracle so as to cause conformational change in that receptor, while closely related farnesoid pathway metabolites do not have this interaction with USP.
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Role of USP Ligand Binding Pocket During Development
  • 批准号：
    7103493
  • 项目类别：
  • 资助金额：
    $29.33万
  • 财政年份：
    2005
  • 负责人：
    GRACE M JONES
  • 依托单位：
    UNIVERSITY OF KENTUCKY
Role of USP Ligand Binding Pocket During Development
  • 批准号：
    6964831
  • 项目类别：
  • 资助金额：
    $30.0万
  • 财政年份：
    2005
  • 负责人：
    GRACE M JONES
  • 依托单位：
    UNIVERSITY OF KENTUCKY
Role of USP Ligand Binding Pocket During Development
  • 批准号：
    7270045
  • 项目类别：
  • 资助金额：
    $28.48万
  • 财政年份：
    2005
  • 负责人：
    GRACE M JONES
  • 依托单位：
    UNIVERSITY OF KENTUCKY
Role of USP Ligand Binding Pocket During Development
  • 批准号：
    7479374
  • 项目类别：
  • 资助金额：
    $28.48万
  • 财政年份：
    2005
  • 负责人：
    GRACE M JONES
  • 依托单位：
    UNIVERSITY OF KENTUCKY
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