Endogenous opioids in the amygdala.

杏仁核中的内源性阿片类药物。

• 批准号: nhmrc : 1047372
• 负责人: A/Pr Elena Bagley
• 金额: $ 25.28万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endogenous-opioids-amygdala/111932
• 关键词: Endogenous; opioids; amygdala.

Debilitating anxiety disorders, such as post-traumatic stress disorder or panic disorder, affect 14% of adult Australians and current therapy is often ineffective. The amygdala is a brain region that is key to learning fear responses but also in reducing our fear responses. This project will determine whether the brain’s own endogenous opioids can modify the activity of the amygdala in order to provide new leads for novel pharmacotherapies with enhanced efficacy.

使人衰弱的焦虑症，如创伤后应激障碍或恐慌症，影响14%的成年澳大利亚人，目前的治疗往往无效。杏仁核是一个大脑区域，它是学习恐惧反应的关键，也是减少恐惧反应的关键。该项目将确定大脑自身的内源性阿片类物质是否可以改变杏仁核的活性，以便为具有增强疗效的新型药物治疗提供新的线索。