Role of GAT-1 transporter channels in opioid dependence

GAT-1转运通道在阿片类药物依赖中的作用

• 批准号: nhmrc : 512390
• 负责人: A/Pr Elena Bagley
• 金额: $ 34.97万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-gat-1-opioid-dependence/99032
• 关键词: Role; GAT; transporter; channels; opioid

Opioid drugs including heroin and morphine are very addictive. After cessation of chronic use of these drugs an intensely unpleasant withdrawal syndrome develops that contributes to relapse. Brain mechanisms that produce withdrawal are still poorly understood. The present work will determine the pathological cellular and molecular mechanisms that produce withdrawal in inhibitory brain nerve cells known to be involved in generating withdrawal discomfort and relapse to compulsive drug use.

包括海洛因和吗啡在内的阿片类药物非常容易上瘾。停止长期使用这些药物后，会出现一种强烈的令人不快的戒断综合征，导致复发。产生戒断的大脑机制仍然知之甚少。目前的工作将确定在抑制性脑神经细胞中产生戒断的病理细胞和分子机制，已知这些细胞参与产生戒断不适和强迫性吸毒复发。