INJECTABLE SENSORS FOR CONTROL OF FES

用于控制 FES 的注射传感器

• 批准号: 6536156
• 负责人: GERALD E LOEB
• 金额: $ 30.59万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-10 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536156
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biosensor device; cats; limbs; medical implant science; neuromuscular stimulator; nonhuman therapy evaluation; paralysis; radio controlled electronic stimulator; telemetry

DESCRIPTION (adapted from the Investigator's abstract): In order to reanimate a paralyzed limb to produce clinically useful movements, three functions must be provided: 1) Electrical stimulators to cause muscles to contract; 2) A controller to coordinate the stimulation; and 3) Sensors of command and feedback signals from the patient to the controller. The investigators have recently completed development and preclinical testing of a novel stimulation technology that permits large numbers of individual muscles to be precisely controlled by injectable, wireless microstimulators that receive power and data by RF transmission from an external controller. They propose to extend that technology by incorporating and testing various types of sensors in similar injectable modules. These will use a novel, compatible system for RF back-telemetry to send signals out of the limb for command and feedback purposes. Their immediate goal is a family of generic "BIONs" (bionic neurons)-that can be configured flexibly to serve a wide range of Functional Electrical Stimulation (FES) applications. The investigators have selected the following basic sensing modalities: 1) Low-level bioelectric signal recording such as electromyography, to monitor (the) level of electrical recruitment (M-waves) and spontaneous activity from muscles with some remaining voluntary control (useful as myoelectric commands for prostheses);and 2) Triangulation of relative position between devices, to be used for determining limb posture Acceleration and inclination (vs. gravity), using microelectromachined silicon (MEMS) sensor technology. The research will proceed in overlapping stages, the first of which is already underway in pilot work: 1) Design, build and test the basic circuit functions for low-level, low-power signal detection, digitization and telemetric transmission; 2) Design, build and test specialized MEMS sensors; 3) Build complete injectable BIONs with sensing and back-telemetry capabilities; 4) Perform preclinical tests of sensor BIONs for biocompatibility; 5) Test sensing and telemetry functions in vitro with artificially-generated inputs; and 6) Test sensing and telemetry functions in alert, behaving animals.

描述（改编自研究者摘要）：为了使一个 瘫痪的肢体要产生临床上有用的运动，必须具备三种功能， 提供：1）电刺激器，使肌肉收缩; 2）A 控制器，以协调刺激;以及3）命令传感器， 从患者到控制器的反馈信号。调查人员已 最近完成了一种新型刺激的开发和临床前测试， 这项技术可以让大量的肌肉精确地 由可注射的无线微刺激器控制， 通过来自外部控制器的RF传输。他们建议延长 通过在类似的环境中整合和测试各种类型的传感器， 可注射模块。这些将使用一种新颖的，兼容的系统， 反向遥测，将信号从肢体中发送出来， 目的他们的直接目标是一个家庭的通用“生物”（仿生 神经元）-可以灵活配置，以服务于广泛的功能 电刺激（FES）应用。调查人员选择了 1）低水平生物电信号记录 例如肌电图，以监测电募集的水平 （M波）和肌肉的自发活动， 控制（可用作假肢的肌电命令）;以及2）三角测量 器械之间的相对位置，用于确定肢体姿势 加速度和倾斜度（与重力），使用微电子加工硅 MEMS传感器技术。研究将分阶段进行， 其中第一个已经在试点工作中进行：1）设计，建造和测试 低电平、低功耗信号检测、数字化的基本电路功能 2）设计、制造和测试专用MEMS 传感器; 3）构建具有传感和反向遥测的完整可注射BION 能力; 4）执行传感器BION的临床前测试， 生物相容性; 5）在体外测试感测和遥测功能， 人工生成的输入;以及6）测试传感和遥测功能， 警觉的行为动物