Endosomal reactive oxygen species in tumour angiogenesis

肿瘤血管生成中的内体活性氧

• 批准号: nhmrc : GNT1128276
• 负责人: Dr Stavros Selemidis
• 金额: $ 63.37万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endosomal-reactive-oxygen-tumour-angiogenesis/1347679
• 关键词: Endosomal; reactive; oxygen; species; tumour

Cancer claims more lives worldwide than any other disease affecting millions of people annually. Tumours grow and spread in the body by acquiring their own blood vessels that provide them with nutrients and oxygen. We have identified a new protein called NADPH oxidase that promotes the development of these new blood vessels in tumours. We propose to test new drugs that block NADPH oxidase activity to stop the development of new blood vessels for the potential treatment of cancer

癌症在全世界夺去的生命比任何其他疾病都多，每年影响数百万人。肿瘤通过获得为它们提供营养和氧气的自己的血管在体内生长和扩散。我们已经发现了一种名为NADPH氧化酶的新蛋白质，它可以促进肿瘤中这些新血管的发育。我们建议测试阻断NADPH氧化酶活性的新药，以阻止新血管的发育，用于潜在的癌症治疗。