CORE--EXPOSURE AND HEALTH EFFECTS

核心——暴露和健康影响

• 批准号: 6587324
• 负责人: MORTON LIPPMANN
• 金额: $ 22.85万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-15 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587324
• 关键词: air pollution; air sampling /monitoring; biomedical facility; clinical research; environmental exposure; environmental health; environmental radiation; environmental toxicology; human subject; occupational hazard; pollution related respiratory disorder; radiobiology

This program, under the direction of Dr. Morton Lippmann, includes eighteen active projects being conducted by five full-time and three part-time members. The primary objective of this research program is to improve the scientific basis and techniques for assessing human exposure, and to apply state-of-the-art knowledge for establishing direct relationships among human exposure to environmental toxicants, resulting doses to target sites, and their directly measurable health outcomes. A range of activities, extending from air sampling and analytical methods development to in-vivo retention measurements and micro-environmental modeling is included. The factors determining internal dose from inhaled toxicants are investigated through studies of regional and intrabronchial particle and vapor deposition and clearance, and through studies in radionuclide metabolism. Field studies are also being conducted of exposure-response relationships in natural populations, especially those involving ambient air exposures and physiological and symptomatic responses.

这个项目在莫顿·李普曼博士的指导下， 包括由5名全职人员和3名全职人员执行的18个正在进行的项目 兼职会员。这项研究计划的主要目标是 改进评估人体接触的科学基础和技术，以及 应用最先进的知识建立直接关系 在人类暴露于环境毒物中，由此产生的目标剂量 以及它们的可直接测量的健康结果。一系列活动， 从空气采样和分析方法发展到体内 包括保留量测量和微环境建模。这个 调查决定吸入毒物内剂量的因素。 通过对区域和支气管内颗粒和气相沉积的研究 和清除，并通过对放射性核素代谢的研究。田野调查 也正在进行暴露-反应关系的自然 人群，特别是那些涉及环境空气暴露和 生理和症状反应。