CORE--EXPOSURE AND HEALTH EFFECTS

核心——暴露和健康影响

• 批准号: 6587324
• 负责人: MORTON LIPPMANN
• 金额: $ 22.85万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-15 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587324
• 关键词: air pollution; air sampling /monitoring; biomedical facility; clinical research; environmental exposure; environmental health; environmental radiation; environmental toxicology; human subject; occupational hazard; pollution related respiratory disorder; radiobiology

This program, under the direction of Dr. Morton Lippmann, includes eighteen active projects being conducted by five full-time and three part-time members. The primary objective of this research program is to improve the scientific basis and techniques for assessing human exposure, and to apply state-of-the-art knowledge for establishing direct relationships among human exposure to environmental toxicants, resulting doses to target sites, and their directly measurable health outcomes. A range of activities, extending from air sampling and analytical methods development to in-vivo retention measurements and micro-environmental modeling is included. The factors determining internal dose from inhaled toxicants are investigated through studies of regional and intrabronchial particle and vapor deposition and clearance, and through studies in radionuclide metabolism. Field studies are also being conducted of exposure-response relationships in natural populations, especially those involving ambient air exposures and physiological and symptomatic responses.

该计划在莫顿·利普曼博士的指导下 包括五个全职和三个活动的18个活跃项目 兼职成员。该研究计划的主要目的是 改善评估人类暴露的科学基础和技术，并 应用最先进的知识来建立直接关系 在人类接触环境有毒物质中，导致剂量 站点及其直接可测量的健康结果。一系列活动， 从空气采样和分析方法发展到体内 包括保留测量和微环境建模。这 研究了确定内部剂量从吸入毒物的因素 通过研究区域和内部粒子和蒸气沉积 和清除，以及通过对放射性核素代谢的研究。现场研究 也在自然中进行暴露响应关系 人口，尤其是涉及环境空气暴露的人群 生理和症状反应。