REGIONAL DEPOSITION OF INHALED PARTICLES IN MAN

吸入颗粒在人体内的区域沉积

• 批准号: 3249441
• 负责人: MORTON LIPPMANN
• 金额: $ 6.35万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-29 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3249441
• 关键词: adult human (21+); aerosols; air pollution; autoradiography; biomaterials; bronchus; child (0-11); diffusion; dust; environmental toxicology; fluorocarbon polymers; human tissue; larynx; lung; lung alveolus; mathematical model; model; oscillography; pollution related respiratory disorder; psychophysiology; radiotracer; respiratory airway volume; respiratory disorder diagnosis; respiratory disorder epidemiology; respiratory function; respiratory neoplasm; respiratory system; respiratory toxin; scanning electron microscopy; silicone rubber; surface property; technetium; trachea

Experimental studies will be performed to determine the range of sizes of the bronchial and alveolar airspaces in human lungs and the effects of variations in airspace dimensions on the regional deposition of inhaled particles. Measurements of in vivo particle deposition will be made, for both cigarette smokers and nonsmokers, with monodisperse aerosols of triphenyl phosphate and ferric oxide, the latter being tagged with 99mTc or 198Au. Concurrently, a series of sequential measurements will be made on the freshly excised lungs of adult smokers, nonsmokers, and children dying accidentally, and on hollow airway casts and tissue sections made from these lungs. Measurements will include: respiratory mechanical function, airspace sizes using aerosol probes, bronchial airway morphometry on solid lung casts, intrabronchial deposition patterns in hollow airway casts, and alveolar airspace dimension on lung sections. In addition, similar techniques will be applied in tests performed on donkeys, involving in vivo aerosol deposition, sacrifice, tests of mechanical function and aerosol deposition in their excised lungs, preparation of lung casts and tissue sections, and measurements of particle deposition and airspace sizes in them. Direct comparisons will be between in vivo airspace sizes and those measured in the casts and sections, and between airspace sizes and particle deposition. The results of all of these tests will be incorporated into predictive deposition models which take anatomic variability into account, including variability associated with age, cigarette smoking, and constitutional factors.

将进行实验研究以确定大小的范围 人肺中的支气管和肺泡空域以及变化的影响 吸入颗粒区域沉积的空域尺寸。 将对两种香烟进行体内颗粒沉积的测量 吸烟者和非吸烟者，带有三苯基磷酸盐的单分散气溶胶 氧化铁，后者用99mtc或198au标记。 同时，a 将在新鲜切除的肺部进行一系列顺序测量 成人吸烟者，非吸烟者和儿童偶然死亡，在空心气道上 这些肺部制成的铸造和组织切片。 测量将包括： 呼吸机械功能，使用气溶胶探针，支气管 固体肺铸件上的气道形态计量学，内部会内沉积模式 空心气道铸件和肺部圆顶尺寸。 在 此外，将在驴上进行的测试中应用类似的技术， 涉及体内气溶胶沉积，牺牲，机械功能测试 在切除的肺中沉积和气溶胶沉积，肺部铸造的准备和 组织切片，以及粒子沉积和空域大小的测量 他们。 直接比较将在体内空域尺寸和那些之间进行比较 在铸件和部分中测量，空域大小和粒子之间 沉积。 所有这些测试的结果将纳入预测 沉积模型考虑了解剖变异性，包括 与年龄，吸烟和宪法因素相关的可变性。