REGIONAL DEPOSITION OF INHALED PARTICLES IN MAN

将进行实验研究，以确定 人肺内的支气管腔和肺泡腔及其变异的影响 空气空间尺寸对可吸入颗粒物区域沉积的影响。 将对这两种香烟进行体内颗粒沉积的测量 吸烟者和不吸烟者，使用单分散的磷酸三苯酯和 氧化铁，后者用99mTc或198Au标记。同时，一个 将对新鲜切除的肺进行一系列连续测量 成人吸烟者、不吸烟者和儿童在中空呼吸道意外死亡 用这些肺制成的管型和组织切片。衡量标准将包括： 呼吸机械功能，使用气雾剂探头的空域大小，支气管 实体肺铸型、支气管内沉积模式的气道形态测量 肺切片上的中空气道管型和肺泡空隙的大小。在……里面 此外，类似的技术将应用于在驴身上进行的测试， 涉及体内气溶胶沉积、牺牲、机械功能测试 和气溶胶在切除的肺中沉积，肺铸型的准备和 组织切片，以及粒子沉积和空气空间尺寸的测量 他们。将在活体空域大小和那些 在投射和截面以及空域大小和颗粒之间进行测量 证词。 所有这些测试的结果都将被合并到预测中 考虑到解剖可变性的沉积模型，包括 变异性与年龄、吸烟和体质因素有关。

Experimental studies will be performed to determine the range of sizes of the bronchial and alveolar airspaces in human lungs and the effects of variations in airspace dimensions on the regional deposition of inhaled particles. Measurements of in vivo particle deposition will be made, for both cigarette smokers and nonsmokers, with monodisperse aerosols of triphenyl phosphate and ferric oxide, the latter being tagged with 99mTc or 198Au. Concurrently, a series of sequential measurements will be made on the freshly excised lungs of adult smokers, nonsmokers, and children dying accidentally, and on hollow airway casts and tissue sections made from these lungs. Measurements will include: respiratory mechanical function, airspace sizes using aerosol probes, bronchial airway morphometry on solid lung casts, intrabronchial deposition patterns in hollow airway casts, and alveolar airspace dimension on lung sections. In addition, similar techniques will be applied in tests performed on donkeys, involving in vivo aerosol deposition, sacrifice, tests of mechanical function and aerosol deposition in their excised lungs, preparation of lung casts and tissue sections, and measurements of particle deposition and airspace sizes in them. Direct comparisons will be between in vivo airspace sizes and those measured in the casts and sections, and between airspace sizes and particle deposition. The results of all of these tests will be incorporated into predictive deposition models which take anatomic variability into account, including variability associated with age, cigarette smoking, and constitutional factors.