REGIONAL DEPOSITION OF INHALED PARTICLES IN MAN
吸入颗粒在人体内的区域沉积
基本信息
- 批准号:3249441
- 负责人:
- 金额:$ 6.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1982
- 资助国家:美国
- 起止时间:1982-09-29 至 1986-08-31
- 项目状态:已结题
- 来源:
- 关键词:adult human (21+) aerosols air pollution autoradiography biomaterials bronchus child (0-11) diffusion dust environmental toxicology fluorocarbon polymers human tissue larynx lung lung alveolus mathematical model model oscillography pollution related respiratory disorder psychophysiology radiotracer respiratory airway volume respiratory disorder diagnosis respiratory disorder epidemiology respiratory function respiratory neoplasm respiratory system respiratory toxin scanning electron microscopy silicone rubber surface property technetium trachea
项目摘要
Experimental studies will be performed to determine the range of sizes of the
bronchial and alveolar airspaces in human lungs and the effects of variations in
airspace dimensions on the regional deposition of inhaled particles.
Measurements of in vivo particle deposition will be made, for both cigarette
smokers and nonsmokers, with monodisperse aerosols of triphenyl phosphate and
ferric oxide, the latter being tagged with 99mTc or 198Au. Concurrently, a
series of sequential measurements will be made on the freshly excised lungs of
adult smokers, nonsmokers, and children dying accidentally, and on hollow airway
casts and tissue sections made from these lungs. Measurements will include:
respiratory mechanical function, airspace sizes using aerosol probes, bronchial
airway morphometry on solid lung casts, intrabronchial deposition patterns in
hollow airway casts, and alveolar airspace dimension on lung sections. In
addition, similar techniques will be applied in tests performed on donkeys,
involving in vivo aerosol deposition, sacrifice, tests of mechanical function
and aerosol deposition in their excised lungs, preparation of lung casts and
tissue sections, and measurements of particle deposition and airspace sizes in
them. Direct comparisons will be between in vivo airspace sizes and those
measured in the casts and sections, and between airspace sizes and particle
deposition.
The results of all of these tests will be incorporated into predictive
deposition models which take anatomic variability into account, including
variability associated with age, cigarette smoking, and constitutional factors.
将进行实验研究,以确定
人肺内的支气管腔和肺泡腔及其变异的影响
空气空间尺寸对可吸入颗粒物区域沉积的影响。
将对这两种香烟进行体内颗粒沉积的测量
吸烟者和不吸烟者,使用单分散的磷酸三苯酯和
氧化铁,后者用99mTc或198Au标记。同时,一个
将对新鲜切除的肺进行一系列连续测量
成人吸烟者、不吸烟者和儿童在中空呼吸道意外死亡
用这些肺制成的管型和组织切片。衡量标准将包括:
呼吸机械功能,使用气雾剂探头的空域大小,支气管
实体肺铸型、支气管内沉积模式的气道形态测量
肺切片上的中空气道管型和肺泡空隙的大小。在……里面
此外,类似的技术将应用于在驴身上进行的测试,
涉及体内气溶胶沉积、牺牲、机械功能测试
和气溶胶在切除的肺中沉积,肺铸型的准备和
组织切片,以及粒子沉积和空气空间尺寸的测量
他们。将在活体空域大小和那些
在投射和截面以及空域大小和颗粒之间进行测量
证词。
所有这些测试的结果都将被合并到预测中
考虑到解剖可变性的沉积模型,包括
变异性与年龄、吸烟和体质因素有关。
项目成果
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MORTON LIPPMANN其他文献
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