Towards therapeutic modulation of amyloid beta clearance from the brain during sleep

睡眠期间大脑中β淀粉样蛋白清除的治疗性调节

• 批准号: 1978541
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1978541
• 关键词: Towards; therapeutic; modulation; amyloid; beta

Evidence is building that sleep disturbances in healthy people, repeated over years, might trigger or accelerate pathological processes leading to dementia, e.g. by causing oxidative stress or enhancing amyloid deposition. The project will address how sleep influences the initiation and progression of the neuropathology of Alzheimer's disease. We are interested particularly in understanding the earliest events responsible for driving the onset of disease pathology in people at risk. The work will focus on questions such as: By what mechanism(s) do soluble amyloid levels decrease in NREM sleep? Does chronic sleep deprivation hinder microglia responses or down regulate their ability to tackle amyloid plaques?

越来越多的证据表明，健康人的睡眠障碍，多年来反复出现，可能会引发或加速导致痴呆症的病理过程，例如通过引起氧化应激或增强淀粉样蛋白沉积。该项目将解决睡眠如何影响阿尔茨海默病神经病理学的启动和进展。我们特别感兴趣的是了解导致高危人群发病的最早期事件。这项工作将集中在这样的问题：通过什么机制（S）做可溶性淀粉样蛋白水平在NREM睡眠下降？慢性睡眠剥夺是否会阻碍小胶质细胞的反应或下调其处理淀粉样斑块的能力？

项目成果

A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.

• DOI: 10.1016/j.cub.2018.05.054
• 发表时间: 2018-07-23
• 期刊: Current biology : CB
• 作者: Harding EC;Yu X;Miao A;Andrews N;Ma Y;Ye Z;Lignos L;Miracca G;Ba W;Yustos R;Vyssotski AL;Wisden W;Franks NP
• 通讯作者: Franks NP