A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.
A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.
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DOI：
10.1016/j.cub.2018.05.054
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发表时间：
2018-07-23
期刊：
影响因子：
--
通讯作者：
Franks NP
中科院分区：
文献类型：
--
作者：
Harding EC;Yu X;Miao A;Andrews N;Ma Y;Ye Z;Lignos L;Miracca G;Ba W;Yustos R;Vyssotski AL;Wisden W;Franks NP
哺乳动物，包括人类，通过筑巢和/或蜷缩来准备睡觉，创造皮肤温暖的小气候。为了解决外部温暖是否通过定义的电路诱发睡眠，我们使用了c- fos依赖的活动标记，捕获激活的细胞群，并允许它们被重新激活以测试它们的生理作用。外部加热标记了下丘脑中部视前区(MnPO)/内侧视前区（MPO）的两组主要神经元。主要位于MPO的GABA神经元产生非快速眼动（NREM）睡眠，但没有体温下降。MnPO-MPO中的氮能-谷氨酸能神经元诱导身体降温和NREM睡眠。这个回路解释了皮肤变暖是如何诱发睡眠的，以及为什么核心身体冷却的最大速率与睡眠的开始呈正相关。因此，促进非快速眼动睡眠、减少能量消耗和身体降温的途径是不可分割地联系在一起的，由相同的神经元控制。这意味着非快速眼动睡眠的一个功能是降低大脑温度和/或保存能量。视前区的氮能-谷氨酸能神经元受到外界温暖的刺激而兴奋，这些神经元的再激活会导致体温下降和非快速眼动睡眠，这种回路将温暖刺激、非快速眼动睡眠和身体冷却结合在一起。Harding等人发现下丘脑MnPO-MPO中的氮能/谷氨酸能神经元，在受到温暖的外部刺激的活动标记后，当重新激活时，会导致睡眠和体温过低。这表明睡眠和身体降温有着千丝万缕的联系。然而，重新激活gaba能神经元只会诱发睡眠。
Mammals, including humans, prepare for sleep by nesting and/or curling up, creating microclimates of skin warmth. To address whether external warmth induces sleep through defined circuitry, we used c-Fos-dependent activity tagging, which captures populations of activated cells and allows them to be reactivated to test their physiological role. External warming tagged two principal groups of neurons in the median preoptic (MnPO)/medial preoptic (MPO) hypothalamic area. GABA neurons located mainly in MPO produced non-rapid eye movement (NREM) sleep but no body temperature decrease. Nitrergic-glutamatergic neurons in MnPO-MPO induced both body cooling and NREM sleep. This circuitry explains how skin warming induces sleep and why the maximal rate of core body cooling positively correlates with sleep onset. Thus, the pathways that promote NREM sleep, reduced energy expenditure, and body cooling are inextricably linked, commanded by the same neurons. This implies that one function of NREM sleep is to lower brain temperature and/or conserve energy. Nitrergic-glutamatergic neurons in the preoptic area are excited by external warmth Reactivation of these neurons induced a drop in body temperature and NREM sleep This circuitry binds a warm stimulus, NREM sleep, and body cooling Harding et al. identify nitrergic/glutamatergic neurons in the MnPO-MPO hypothalamus, which after activity tagging by a warm external stimulus induce both sleep and hypothermia when reactivated. This suggests sleep and body cooling are inextricably linked. Reactivating GABAergic neurons, however, induces only sleep.
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影响因子：
3.5
作者：
FRANKEN, P;TOBLER, I;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
25
作者：
Eban-Rothschild A;Rothschild G;Giardino WJ;Jones JR;de Lecea L
通讯作者：
de Lecea L
影响因子：
15.9
作者：
Krashes, Michael J.;Koda, Shuichi;Lowell, Bradford B.
通讯作者：
Lowell, Bradford B.
影响因子：
5.7
作者：
Eban-Rothschild A;Giardino WJ;de Lecea L
通讯作者：
de Lecea L
DOI：
10.1073/pnas.0913358107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Nakamura, Kazuhiro;Morrison, Shaun F.
通讯作者：
Morrison, Shaun F.