CORE-- EXPERIMENTAL PATHOLOGY

核心——实验病理学

• 批准号: 6577774
• 负责人: Robert Clark Lantz
• 金额: $ 22.86万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577774
• 关键词: biomedical facility; histopathology

The objective of the Experimental Pathology Service Core is to provide Center members both routine and advanced capabilities in the visualization and quantitation of structural and in situ molecular alterations to tissues and cells following exposures to toxicants. The Core provides a number of services. These include: standard microscopic services; expertise in experimental design and implementation of morphological techniques; quantitative structural analysis and interpretation of morphological alterations; instrumentation and expertise for specialized imaging technique; and training, consultation and technical assistance for users. Over the last budget period, 40 Center members from all Research Cores used the services of this Core. The development of the Experimental Pathology Service Core is the result of the bringing together of service facilities for microscopy and imaging that already exist at the University of Arizona. The Core supports these facilities through its budget, oversight and faculty. To insure that the needs of Center members are met, an advisory committee was formed in 1997. The development of these facilities has been accomplished from various institutional mechanisms which provides the space (>4500 sq. ft.), supports technical staff (5.5 FTES), maintains service contracts and contributes to the purchase of instrumentation. The facilities available to the Core include: a Histology Service Core Laboratory (653 sq. ft.) located in the Department of Cell Biology and Anatomy; various Imaging Facilities which include equipment and personnel to perform electron microscopy, confocal microscopy and digital image analysis; a developing cell and molecular imaging resource in the Arizona Cancer Center. The primary use of the Core has been histological analysis. However, in response to the needs of Center investigators the Core will be expanding in two directions: application of molecular biological techniques to microscopic imaging; and digital image analysis and manipulation. The first direction will be accomplished by the increased effort (from 10 to 25%) of Dr. Claire Payne and the second through acquisition of new image analysis equipment which will allow investigators to directly image tissue sections and cells.

实验病理学服务中心的目标是 为中心成员提供常规和高级能力， 结构和原位分子改变的可视化和定量 对组织和细胞的毒性核心提供了一个 服务的数量。这些服务包括：标准显微镜服务;专业知识 形态学技术的实验设计和实施; 定量结构分析和形态解释 改造;专门成像技术的仪器和专门知识; 为用户提供培训、咨询和技术援助。在过去 在预算期间，来自所有研究中心的40名中心成员使用了 这个核心。实验病理学服务核心的发展是 由于汇集了显微镜服务设施， 已经存在于亚利桑那大学的图像。芯支承件而 这些设施通过其预算，监督和教师。以确保 为了满足中心成员的需要，1997年成立了一个咨询委员会。 这些设施的发展已经完成了从各种 提供空间的体制机制（>4500平方米）ft.），支持 技术人员（5.5 FTES），维护服务合同， 购买仪器。核心可利用的设施包括： 组织学服务核心实验室（653平方米）英尺）。位于 细胞生物学和解剖学;各种成像设施，包括设备 和人员进行电子显微镜，共聚焦显微镜和数字 图像分析;发展中的细胞和分子成像资源 亚利桑那州癌症中心。核心的主要用途是组织学 分析.然而，为了满足中心研究人员的需求， 将向两个方向拓展：分子生物学的应用 显微成像技术;数字图像分析， 操纵第一个方向将通过增加 Claire Payne博士的努力（从10%到25%）和第二次通过收购 新的图像分析设备，这将使调查人员直接 对组织切片和细胞进行成像。