3D optical histopathology for head and neck intraoperative consultation.

用于头颈部术中咨询的 3D 光学组织病理学。

基本信息

  • 批准号:
    10379553
  • 负责人:
  • 金额:
    $ 26.3万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary Intraoperative consultations (IOC, often refers to frozen-section histopathology during surgery) significantly improve the outcome of many oncological surgeries. However, even though this procedure generates results much faster than traditional formalin-fixed paraffin-embedded (FFPE) histopathology, it is still lengthy for time- sensitive surgeries such as head and neck tumor resections. Surgeries often need to be paused during the IOC, leading to an expensive waste of operating room time and resources. Because IOC usually requires a fast turnaround, only a few slices can be prepared and evaluated at a time. Miscommunication between surgeons and pathologists leads to sampling errors. Freezing artifacts result in degraded histology quality. These limitations increase the risk of missing important histopathology information in the slice, resulting in false- negative margins which affects the success rate and long-term outcomes of cancer surgeries. Thus, there is a need for faster and more reliable intraoperative histopathology evaluation. To address these limitations, we propose to develop an alternative histology framework for intraoperative histopathology assessment using a combination of optical clearing and 3D imaging technologies developed in our lab. Our proposed product will provide 3D histology information of intraoperative specimens with a faster and simpler workflow than the incumbent solution. The product comprises three major components: 1) a rapid tissue processing pipeline that makes tissue transparent with a few washes, 2) a user-friendly imaging system that enables real-time 3D microscopy imaging of the transparent whole-mount clinical specimens, 3) A software user interface that translates the 3D data into 2D images with pathologist-familiar color contrast and assists the pathologist in interpreting the data. 3D virtual histology has been proposed as an alternative to slice-based histopathology to provide more accurate diagnoses. However, current 3D virtual histopathology techniques often have high complexity and long turnaround time. Our preliminary customer discovery suggested it was highly challenging for histology labs to incorporate these new techniques into the existing well-established workflow due to high capital cost and complexity. By simplifying the sample preparation into 2-3 fluid washes and providing a plug- and-play 3D imaging device that requires minimal calibration and maintenance, our product will enable 3D virtual histopathology that is easier, faster, and more accurate than the traditional methods.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

YEHE LIU其他文献

YEHE LIU的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('YEHE LIU', 18)}}的其他基金

3D optical histopathology for head and neck intraoperative consultation.
用于头颈部术中咨询的 3D 光学组织病理学。
  • 批准号:
    10578781
  • 财政年份:
    2022
  • 资助金额:
    $ 26.3万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 26.3万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了