CORE--ANIMAL MODELS

核心--动物模型

• 批准号: 6564256
• 负责人: YVETTE FRANCE TACHE
• 金额: $ 14.67万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564256
• 关键词: biological models; biomedical facility; blood flow measurement; disease /disorder model; electrophysiology; gastrointestinal disorder; gastrointestinal function; laboratory mouse; laboratory rat; model design /development; neuroregulation

DESCRIPTION (Adapted from the application) The overall objectives of the core are to provide facilities and expertise to researchers for in vivo characterization of normal and pathophysiological mechanisms of hormonal and neural regulation of GI function and brain gut interactions. They provide the investigators with 1. In vivo experimental models to assess gastric, pancreatic, and intestinal function in rats, mice, and other species; 2. Specialized facilities and equipment for measuring GI secretory, motor, and nerve functions; 3. Methods for in vivo administration of peptides, neurotransmitters, and drugs, sampling blood and body fluids, and removing tissues; 4. Methods to assess afferent and efferent arms of the pathways in brain-gut interactions; and 5. Expertise in protocol design and data interpretation for in vivo studies.

描述（改编自应用程序）核心的总体目标 为研究人员提供设备和专业知识， 表征正常和病理生理机制的激素和 胃肠道功能和脑肠道相互作用的神经调节。他们提供 调查人员1。体内实验模型来评估胃， 大鼠、小鼠和其他物种的胰腺和肠功能; 2. 专门的设施和设备，用于测量GI分泌，运动， 神经功能; 3.肽的体内给药方法， 神经递质和药物，血液和体液取样， 组织; 4.方法评估传入和传出臂的途径， 脑-肠相互作用;以及5.方案设计和数据方面的专业知识 用于体内研究的解释。