CORE--ANIMAL MODELS

核心--动物模型

• 批准号: 6564256
• 负责人: YVETTE FRANCE TACHE
• 金额: $ 14.67万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564256
• 关键词: biological models; biomedical facility; blood flow measurement; disease /disorder model; electrophysiology; gastrointestinal disorder; gastrointestinal function; laboratory mouse; laboratory rat; model design /development; neuroregulation

DESCRIPTION (Adapted from the application) The overall objectives of the core are to provide facilities and expertise to researchers for in vivo characterization of normal and pathophysiological mechanisms of hormonal and neural regulation of GI function and brain gut interactions. They provide the investigators with 1. In vivo experimental models to assess gastric, pancreatic, and intestinal function in rats, mice, and other species; 2. Specialized facilities and equipment for measuring GI secretory, motor, and nerve functions; 3. Methods for in vivo administration of peptides, neurotransmitters, and drugs, sampling blood and body fluids, and removing tissues; 4. Methods to assess afferent and efferent arms of the pathways in brain-gut interactions; and 5. Expertise in protocol design and data interpretation for in vivo studies.

描述(改编自应用程序)核心的总体目标 是为研究人员提供体内研究的设施和专业知识 激素性和非激素性高血压的正常和病理生理机制特征 胃肠功能的神经调节和大脑肠道的相互作用。它们提供了 研究人员用1.活体实验模型评估胃部， 大鼠、小鼠等物种的胰腺、肠道功能； 用于测量GI分泌物、运动量和 神经功能；3.多肽的体内给药方法， 神经递质和药物，采集血液和体液，并清除 组织；4.评估路径的传入和传出臂的方法 大脑-肠道相互作用；以及5.协议设计和数据方面的专业知识 活体研究的解释。