CORE--ANIMAL MODELS

核心--动物模型

• 批准号: 6564256
• 负责人: YVETTE FRANCE TACHE
• 金额: $ 14.67万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564256
• 关键词: biological models; biomedical facility; blood flow measurement; disease /disorder model; electrophysiology; gastrointestinal disorder; gastrointestinal function; laboratory mouse; laboratory rat; model design /development; neuroregulation

DESCRIPTION (Adapted from the application) The overall objectives of the core are to provide facilities and expertise to researchers for in vivo characterization of normal and pathophysiological mechanisms of hormonal and neural regulation of GI function and brain gut interactions. They provide the investigators with 1. In vivo experimental models to assess gastric, pancreatic, and intestinal function in rats, mice, and other species; 2. Specialized facilities and equipment for measuring GI secretory, motor, and nerve functions; 3. Methods for in vivo administration of peptides, neurotransmitters, and drugs, sampling blood and body fluids, and removing tissues; 4. Methods to assess afferent and efferent arms of the pathways in brain-gut interactions; and 5. Expertise in protocol design and data interpretation for in vivo studies.

描述（改编自申请）核心的总体目标 为研究人员提供体内研究的设施和专业知识 荷尔蒙和病理生理机制的表征 胃肠道功能和脑肠相互作用的神经调节。他们提供 1. 体内实验模型来评估胃、 大鼠、小鼠和其他物种的胰腺和肠道功能； 2. 用于测量胃肠道分泌、运动和代谢的专用设施和设备 神经功能； 3.肽的体内施用方法， 神经递质和药物，采集血液和体液样本，并去除 纸巾； 4. 评估通路传入和传出臂的方法 脑肠相互作用； 5. 协议设计和数据方面的专业知识 体内研究的解释。