C0RE--ANIMAL MODELS

C0RE--动物模型

• 批准号: 7415061
• 负责人: YVETTE FRANCE TACHE
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7415061
• 关键词: Animal Model; Animals; Blood flow; Blood specimen; Body Fluids; Brain; Data Analyses; Digestive System Disorders; Equipment; Experimental Models; Gene Mutation; Hormonal; Injury; Intestines; Maps; Measures; Methods; Motor; Mucous Membrane; Mus; Neural Pathways; Neurons; Neurotransmitters; Peptides; Pharmaceutical Preparations; Program Development; Protocols documentation; Rattus; Research; Research Personnel; Resistance; Rodent; Stomach; Tissue Banks; Transgenic Animals; Transgenic Organisms; Upper arm; design; gastrointestinal; gastrointestinal function; in vivo; member; neuroregulation

The overall objective of the Animal Models Core is to provide expertise to members of the CURE: Digestive Diseases Research Core Center (CURE: DDRCC) for in vivo characterization of normal and pathophysiological mechanisms of hormonal and neural regulation of gastrointestinal (GI) function and brain-gut interactions in rodents. The specific objectives are to provide CURE: DDRCC investigators access to: (1) in vivo experimental models to assess gastric and intestinal function in rats and mice; (2) specialized facilities and equipment to measure GI secretions, motor function, blood flow, resistance of the mucosa to injury and functional mapping of neuronal activity at the cellular level; (3) methods for in vivo administration of peptides, neurotransmitters, and drugs, sampling blood and body fluids, and tissue collection; (4) methods to assess afferent and efferent arms of the neural pathways involved in brain-gut interactions; (5) expertise in protocol design, data analysis and program development for analysis of electrophysiological traces; and (6) transgenic animals with specific gene mutations through interaction with transgenic Cores within UCLA.

动物模型核心的总体目标是为CURE的成员提供专业知识：