A new class of Two-Dimensional Optoelectronic Materials in Accommodating Intraocular Lens Design

适应人工晶状体设计的新型二维光电材料

• 批准号: 1982487
• 金额: --
• 依托单位: University of Brighton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1982487
• 关键词: new; class; Two; Dimensional; Optoelectronic

Since Rayner and Harold Ridley developed the world's first intraocular lens (IOL) in 1949 there have been huge advances in medical implant technologies. However, there remain significant challenges in IOL design and development related to poor biocompatibility and failure of these medical devices to mimic the accommodative properties of the natural lens. In developing the next generation of implantable ocular devices capable of accommodative vision, sensors, conductive nanomaterials and novel polymers which respond to stimulation from ciliary muscle contraction will be required. Within this project a new class of nanostructured two dimensional materials with optoelectronic properties exceeding those of the related graphene family will be developed for use in implantable ophthalmic devices. This PhD program will utilise the expertise in ophthalmic biomaterials at the University of Brighton & Rayner Intraocular Lenses Ltd (UK), combined with the materials expertise at AJ Drexel Nanomaterials Institute (USA).Cataracts are the leading cause of bilateral blindness globally and affect more than 24 million people worldwide. Whilst removal of the cloudy lens and replacement with a plastic intraocular lens (IOL) restores sight many patients experience difficulties related to loss of visual acuity and accommodation. Accommodating IOL design is currently restricted by the lack of materials which are transparent, flexible and conductive allowing response to ciliary muscle contraction by a change of refractive properties. This project introduces a new class of nanostructured, 2 dimensional materials for accommodating IOL design and will investigate the hypothesis that these materials may be developed as transparent, flexible, highly conductive IOL prototypes which suppress inflammation and respond to stimulus by controlled changes in lens refractive index. These materials may also provide a safe and effective phakic IOL as an alternative and more predictable refractive procedure to laser surgery. The PhD student will gain experience in material synthesis and physicochemical characterisation techniques, biological modelling and commercial aspects of accommodating IOL design. Based primarily in the biomaterials research group, at the University of the Brighton; the student will also spend time learning nanomaterials synthesis and characterisation techniques at AJ Drexel Nanotechnology Institute, USA and will gain industrial experience working at Ridley Innovation Centre, Rayner's new £22 million state of the art training and IOL production facility.

自1949年雷纳和哈罗德·里德利开发出世界上第一台人工晶状体以来，医疗植入技术取得了巨大的进步。然而，人工晶状体的设计和开发仍然面临着巨大的挑战，这与生物相容性差以及这些医疗设备无法模拟天然晶状体的调节特性有关。在开发能够调节视力的下一代植入性眼科设备时，将需要传感器、导电纳米材料和新型聚合物来响应睫状肌收缩的刺激。在该项目中，将开发一类新的纳米结构二维材料，其光电性能超过相关的石墨烯家族，用于植入性眼科设备。这一博士项目将利用英国布莱顿大学雷纳人工晶体有限公司在眼科生物材料方面的专业知识，以及AJ Drexel纳米材料研究所(美国)的材料专业知识。白内障是全球导致双眼失明的主要原因，全球有2400多万人受到影响。虽然去除混浊的晶状体并用塑料人工晶状体(IOL)替换可以恢复视力，但许多患者经历了与丧失视力和调节有关的困难。目前，可调节人工晶状体的设计受到缺乏透明、灵活和导电的材料的限制，这些材料可以通过改变屈光特性来响应睫状肌收缩。该项目引入了一类新的纳米结构的二维材料来适应人工晶状体的设计，并将探索这样一种假设，即这些材料可能被开发成透明、灵活、高传导性的人工晶体原型，通过控制晶状体折射率的变化来抑制炎症和对刺激做出反应。这些材料还可能提供一种安全有效的有晶状体人工晶状体，作为激光手术的一种替代和更可预测的屈光手术。博士生将在材料合成和物理化学表征技术、生物建模和人工晶状体设计的商业方面获得经验。主要在布莱顿大学生物材料研究组工作；该学生还将在美国AJ Drexel纳米技术研究所学习纳米材料合成和表征技术，并将在Ridley创新中心获得工业经验，Ridley创新中心是Rayner新的GB 2200万GB最先进的培训和人工晶状体生产设施。