Endothelial and Mesenchymal Cell Interactions in Pancreatic Beta Cell Differentiation

胰腺β细胞分化中内皮细胞和间充质细胞的相互作用

• 批准号: nhmrc : 1065956
• 负责人: Dr Suzanne Micallef
• 金额: $ 6.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endothelial-mesenchymal-cell-cell-differentiation/455213
• 关键词: Endothelial; Mesenchymal; Cell; Interactions; Pancreatic

Type 1 diabetes is a condition that arises when the body's immune system destroys insulin-producing beta cells within the pancreas. Recent studies have shown that normal glucose control can be restored by replacing the missing beta cells by transplantation of cells from deceased donors. However, the demand for transplant material outweighs supply. The work described in this application seeks to define how insulin-producing beta cells can be derived in the laboratory from embryonic stem cells.

1型糖尿病是一种当身体的免疫系统破坏胰腺内产生胰岛素的β细胞时出现的疾病。最近的研究表明，通过移植来自死亡供体的细胞来替代缺失的β细胞，可以恢复正常的葡萄糖控制。然而，移植材料的需求超过了供应。本申请中描述的工作试图定义如何在实验室中从胚胎干细胞衍生产生胰岛素的β细胞。