The Brain & Psychosis: Asymmetry & cortical organization

大脑

• 批准号: 6529295
• 负责人: Martin Reite
• 金额: $ 37.83万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529295
• 关键词: auditory cortex; behavioral /social science research tag; bipolar depression; bipolar depression manic phase; brain injury; clinical research; cognition; disease /disorder proneness /risk; electroencephalography; hallucinations; human subject; magnetic resonance imaging; magnetoencephalography; neuroanatomy; neuroimaging; psychosis; sensory cortex; temporal lobe /cortex

DESCRIPTION (Adapted from applicant's abstract): The problem of psychosis is not often considered independently from the conditions with which it is associated. Investigations in this laboratory have documented neuromagnetic abnormalities using auditory probe tasks in bipolar patients with a history of psychosis vs. those without such history. This suggests the possibility to differentiate brain variables related to psychosis from those related to the mental illness per se. The investigators now propose to study 30 subjects with bipolar disorder and a history of psychosis, 30 bipolar subjects with no history of psychosis, and 30 controls (15 males in each group). Magnetic source imaging of auditory (M100 generated in Heschl's gyrus or continuous planum temporale) and somatosensory (M50 generated in 3b of postcentral gyrus). MRI data from these subjects will examine, identify and quantify the source of these MEG signals to assess possible cortical reorganization as an index of psychosis. The hypothesis is that subjects with a history of psychosis will demonstrate specific abnormalities on functional and structural measures. Altered tototopy and somatotopy will be examined as antecedents or results of psychosis. The findings will help identify individuals at risk for illness, and separate disease and psychosis-associated brain changes in mental disorders.

描述（改编自申请人的摘要）：精神病的问题是 通常不独立于其所处的条件来考虑 联系。该实验室的研究记录了神经磁 在有以下病史的双相情感障碍患者中使用听觉探针任务发现异常 精神病与没有这种病史的人。这表明有可能 区分与精神病相关的大脑变量和与精神疾病相关的大脑变量 精神疾病本身。研究人员现在提议对 30 名受试者进行研究 双相情感障碍和精神病史，30 名双相情感障碍受试者，无症状 精神病史，以及 30 名对照组（每组 15 名男性）。磁源 听觉成像（在 Heschl 回或连续平面中生成的 M100） 颞叶）和体感（M50 在中央后回 3b 中生成）。核磁共振成像 来自这些受试者的数据将检查、识别和量化 这些 MEG 信号可评估可能的皮质重组，作为以下指标： 精神病。假设有精神病史的受试者会 表现出功能和结构测量上的特定异常。 改变的tototopy和somatotopy将作为前因或结果进行检查 精神病。研究结果将有助于识别有患病风险的个人，以及 精神障碍中与疾病和精神病相关的大脑变化分开。