The Brain & Psychosis: Asymmetry & cortical organization

描述(改编自申请者的摘要)：精神病的问题是 不经常独立于它所处的条件而被考虑 关联的。这个实验室的研究证明了神经磁学 有以下病史的双相情感障碍患者的听觉探测任务异常 精神病VS那些没有这种病史的人。这表明有可能 区分与精神病相关的大脑变量和与精神疾病相关的 精神疾病本身。研究人员现在建议对30名受试者进行 双相情感障碍与精神病史，30例双相情感障碍 精神病史，30名对照组(每组15名男性)。磁源 听觉(Heschl回或连续平面产生的M100)的成像 颞叶)和躯体感觉(M50产生于中央后回的3b)。磁共振成像 来自这些受试者的数据将检查、识别和量化 这些脑磁图信号评估可能的皮质重组作为一个指标 精神错乱。假设是有精神病病史的受试者 在功能和结构措施方面表现出特定的异常。 改变的体位解剖和体位解剖将作为先兆或结果进行检查 精神错乱。这些发现将有助于识别有患病风险的个人，以及 精神障碍中与疾病和精神病相关的脑变化分开。

DESCRIPTION (Adapted from applicant's abstract): The problem of psychosis is not often considered independently from the conditions with which it is associated. Investigations in this laboratory have documented neuromagnetic abnormalities using auditory probe tasks in bipolar patients with a history of psychosis vs. those without such history. This suggests the possibility to differentiate brain variables related to psychosis from those related to the mental illness per se. The investigators now propose to study 30 subjects with bipolar disorder and a history of psychosis, 30 bipolar subjects with no history of psychosis, and 30 controls (15 males in each group). Magnetic source imaging of auditory (M100 generated in Heschl's gyrus or continuous planum temporale) and somatosensory (M50 generated in 3b of postcentral gyrus). MRI data from these subjects will examine, identify and quantify the source of these MEG signals to assess possible cortical reorganization as an index of psychosis. The hypothesis is that subjects with a history of psychosis will demonstrate specific abnormalities on functional and structural measures. Altered tototopy and somatotopy will be examined as antecedents or results of psychosis. The findings will help identify individuals at risk for illness, and separate disease and psychosis-associated brain changes in mental disorders.