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INTEGRATING ENERGY STORAGE, HIPPOCAMPUS AND HORMONES

整合能量储存、海马体和激素

基本信息

批准号：
6539204
负责人：
JEFFREY R LUCAS
金额：
$ 18.15万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2004-06-30
项目状态：
已结题

项目摘要

Seasonal Affective Disorder (SAD) is a seasonal pattern of clinical depression that also correlates with changes in appetite, weight regulation, hormone profiles, and social interactions. This suite of correlated traits (except for the depression) is characteristic of many birds that show dramatic seasonal shifts in energy regulation and social structure as an adaptive anticipatory response or an adaptive reactive response to seasonal environmental changes. Thus, birds may be excellent models for understanding basic physiological processes that are associated with seasonal affective disorders in humans. However, while we understand many of the component parts of these seasonal cycles, we know relatively little about the adaptive significance of the joint regulation of these cycles. To this end, we propose an experiment designed to evaluate the correlated changes in spatial memory, neuroanatomy, hormone profiles, energy regulation patterns and activity budgets in adult Carolina chickadees maintained under natural photoperiods. Carolina chickadees will be used in this study because these birds store food in hundreds to thousands of distinct sites; retrieval of this food is partly dependent on spatial memory. Thus seasonal variation in energy storage patterns should be correlated with seasonal variation in hippocampal formation (HF) and spatial memory capacity. The project includes a yearlong study where adult birds are housed under laboratory conditions with natural photoperiods but constant temperature. Caching rates and body mass will be monitored under constant rates of food access for a 32-day period, then the birds will be given a set of spatial memory tests in which they are allowed to search a room for previously stored seeds. These data will provide a direct comparison between energy regulation tactics and spatial memory capacity. Movement patterns and general time budgets will be generated from focal-animal behavioral samples. After the behavioral tests are completed, we will test for correlated changes in size and cytogenesis in the HF. Cytogenesis will be measured using BrdU injections administered during the spatial memory trials; HF size will be measured on each bird at the end of each experiment. Hormone profiles will be measured from fecal samples taken at dawn and dusk throughout the experiment. Seasonal cycles of depression often correlate with seasonal cycles in a variety of physiological traits. Only an integrative approach will tell us how these cycles relate to on another. An understanding of the adaptive significance of the suite of traits that cycle annually in natural systems will give us a unique insight into this important component of these seasonal disorders.

季节性情感障碍（SAD）是一种季节性的情感障碍。临床抑郁症，也与食欲，体重调节、激素分布和社会互动。这套相关的（除了抑郁症）是许多鸟类的特征，能源监管和社会结构的巨大季节性变化，适应性预期反应或适应性反应，环境变化。因此，鸟类可能是理解与季节性情感相关的基本生理过程人类的疾病。然而，虽然我们了解了许多组成部分，在这些季节性周期中，我们对适应性这些周期的联合调节的意义。为此，我们建议一项旨在评估空间记忆相关变化的实验，神经解剖学、激素谱、能量调节模式和活动预算成年卡罗莱纳山雀保持在自然光周期。卡罗莱纳山雀将被用于这项研究，因为这些鸟类储存食物，数百到数千个不同的地点;这种食物的检索部分是依赖于空间记忆因此，能源储存模式的季节性变化应该与海马结构（HF）的季节性变化相关，空间记忆能力。该项目包括一项为期一年的研究，成年鸟类被安置在实验室条件下的自然光周期，但恒温。将在恒定的食物速率下监测缓存率和体重进入32天的时间，然后鸟类将获得一套空间记忆测试，允许他们在房间里搜索以前存储的东西。种子这些数据将提供能源监管之间的直接比较战术和空间记忆能力。移动模式和一般时间预算将从焦点动物行为样本中产生。在行为测试完成后，我们将测试大小的相关变化， HF中的细胞发生。将使用BrdU注射测量细胞发生在空间记忆试验期间施用; HF大小将在每个每次实验结束时的鸟。将测量激素曲线，在整个实验过程中，在黎明和黄昏采集粪便样本。抑郁症的季节性周期通常与各种季节性周期相关。生理特征的。只有综合的方法才能告诉我们，循环与另一个循环有关。对适应性意义的理解在自然系统中每年循环的一系列特征将给我们一个对这些季节性疾病的重要组成部分的独特见解。