GCRC-CAP-EMILY L. DOBYNS, M.D.

（摘自申请人摘要）：本赠款提案旨在 资助艾米丽·多宾斯博士获得国家卫生研究院CAP奖。 多宾斯医生是董事会的- 认证的儿科医生和UCHSC儿科助理教授。 在儿科重症监护医学研究期间，Dobyns博士 接受过关于类花生酸在体外作用的实验室研究的培训， 新生儿肺循环 这段最初的经历激发了她的兴趣 急性肺损伤的机制。 加盟以来 1991年，Dobyns博士的主要职责是 临床设置，教学，提供病人护理和管理。 在这段时间里，她越来越感兴趣，并参与到 儿科急性低氧性呼吸衰竭（AHRF）的临床研究， 包括一项随机对照多中心试验， 一氧化氮（iNO）在AHRF治疗中的作用。 她还完成了几个 相关项目，包括测量儿科AHRF中的细胞因子水平 和用iNO治疗后的婴儿肺功能。 这些经历 增加了她对临床研究的兴趣，并导致了扩大她的愿望， 这些技能使她能够设计和执行有效的临床试验。 在此之前，这种临床培训的机会还没有 一直可用。 UCHSC现有的设施和Dobyns博士的经验 把她安置在这个训练的理想位置 她近期的职业目标 是：1）成为熟练的技能，需要是一个全面的培训 临床研究者;和2）使用这种培训和互动， 经验丰富的临床研究人员，以更好地了解病理生理学， AHRF的治疗 Dobyns博士的长期职业目标是成为一名 独立临床研究者。 这个奖项将使她获得这些 通过提供：1）在严格的教学中进行监督学习的时间 培训计划旨在提供最佳环境， 学习机制; 2）有足够的时间获得先进的经验 临床研究的方法和实验途径; 3）关闭时间 与经验丰富的导师联系; 4）儿科GCRC的支持 她的研究项目的设施和人员; 5）完善她的临床 随着她的训练进展进行研究;和6）作为一个 临床研究者 该提案详细介绍了一个有组织的计划， 将教学培训和批判性互动与经验丰富的 导师，从而使她能够实现她的长期目标， 作为临床研究者的独立性。

(Adapted from the applicant's abstract): This grant proposal seeks funding for Dr. Emily Dobyns for the NIH CAP Award. Dr. Dobyns is a board- certified pediatrician and Assistant Professor in Pediatrics at the UCHSC. During her fellowship in pediatric critical care medicine, Dr. Dobyns was trained in laboratory research on the in vitro role of eicosanoids in the neonatal pulmonary circulation. This initial experience spawned her interest in the mechanisms of acute lung injury in the clinical setting. Since joining the faculty in 1991, Dr. Dobyns' primary responsibilities have been in the clinical setting, teaching, providing patient care, and administration. During this time, she has become increasingly interested and involved in clinical studies of acute hypoxemic respiratory failure (AHRF) in pediatrics, including a randomized controlled multicenter trial on the effects of inhaled nitric oxide (iNO) in the treatment of AHRF. She has also completed several related projects including measurements of cytokine levels in pediatric AHRF and infant lung function following treatment with iNO. These experiences have increased her interest in clinical research and led to a desire to expand her skills which would enable her to design and execute efficient clinical trials. Prior to this time, opportunities for this level of clinical training have not been available. The facilities available at UCHSC and Dr. Dobyns' experience place her in and ideal position for this training. Her immediate career goals are to: 1) become proficient in the skills needed to be a fully trained clinical-investigator; and 2) to use this training and interaction with experienced clinical researchers to better understand the pathophysiology and treatment of AHRF. Dr. Dobyns' long-term career goal is to become an independent clinical investigator. This award would allow her to attain these goals by providing: 1) time for supervised study within a rigorous didactic training program that has been designed to provide an optimal environment and mechanism for learning; 2) sufficient time to gain experience in advanced methods and experimental approaches in clinical research; 3) time for close association with an experienced mentor; 4) support from the Pediatric GCRC facilities and personnel for her research project; 5) to refine her clinical research as her training progresses; and 6) to achieve independence as a clinical investigator. This proposal details an organized plan for integrating the didactic training and critical interactions with experienced mentors, thereby allowing her to fulfill her long-term goals of achieving independence as a clinical investigator.