GCRC-CAP-EMILY L. DOBYNS, M.D.

GCRC-CAP-Emily L. DOBYNS，医学博士

• 批准号: 6651622
• 负责人: EMILY Louise DOBYNS
• 金额: $ 12.8万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651622
• 关键词: biomarker; child (0-11); clinical research; clinical trials; combination therapy; human subject; human therapy evaluation; inflammation; lung injury; lung lavage; neonatal intensive care; newborn human (0-6 weeks); nitric oxide; oxidative stress; patient care management; pediatric pharmacology; placebos; pulmonary respiration; respiratory disease /disorder therapy; respiratory disorder chemotherapy; respiratory function; respiratory hypoxia; respiratory insufficiency /failure

(Adapted from the applicant's abstract): This grant proposal seeks funding for Dr. Emily Dobyns for the NIH CAP Award. Dr. Dobyns is a board- certified pediatrician and Assistant Professor in Pediatrics at the UCHSC. During her fellowship in pediatric critical care medicine, Dr. Dobyns was trained in laboratory research on the in vitro role of eicosanoids in the neonatal pulmonary circulation. This initial experience spawned her interest in the mechanisms of acute lung injury in the clinical setting. Since joining the faculty in 1991, Dr. Dobyns' primary responsibilities have been in the clinical setting, teaching, providing patient care, and administration. During this time, she has become increasingly interested and involved in clinical studies of acute hypoxemic respiratory failure (AHRF) in pediatrics, including a randomized controlled multicenter trial on the effects of inhaled nitric oxide (iNO) in the treatment of AHRF. She has also completed several related projects including measurements of cytokine levels in pediatric AHRF and infant lung function following treatment with iNO. These experiences have increased her interest in clinical research and led to a desire to expand her skills which would enable her to design and execute efficient clinical trials. Prior to this time, opportunities for this level of clinical training have not been available. The facilities available at UCHSC and Dr. Dobyns' experience place her in and ideal position for this training. Her immediate career goals are to: 1) become proficient in the skills needed to be a fully trained clinical-investigator; and 2) to use this training and interaction with experienced clinical researchers to better understand the pathophysiology and treatment of AHRF. Dr. Dobyns' long-term career goal is to become an independent clinical investigator. This award would allow her to attain these goals by providing: 1) time for supervised study within a rigorous didactic training program that has been designed to provide an optimal environment and mechanism for learning; 2) sufficient time to gain experience in advanced methods and experimental approaches in clinical research; 3) time for close association with an experienced mentor; 4) support from the Pediatric GCRC facilities and personnel for her research project; 5) to refine her clinical research as her training progresses; and 6) to achieve independence as a clinical investigator. This proposal details an organized plan for integrating the didactic training and critical interactions with experienced mentors, thereby allowing her to fulfill her long-term goals of achieving independence as a clinical investigator.

(改编自申请者的摘要)：这项拨款提案旨在 资助艾米丽·多比恩斯博士获得美国国立卫生研究院CAP奖。多比恩斯博士是一个董事会- UCHSC认证儿科医生和儿科学助理教授。 在儿科重症监护医学研究员期间，多比恩斯医生 接受过关于二十烷类化合物体外作用的实验室研究培训 新生儿肺循环。这段最初的经历激起了她的兴趣 在急性肺损伤的发病机制中处于临床地位。自加入以来 1991年，多比恩斯博士的主要职责一直是 临床环境、教学、病人护理和管理。 在这段时间里，她变得越来越感兴趣和参与 儿科急性低氧性呼吸衰竭的临床研究 包括一项关于吸入剂影响的随机对照多中心试验 一氧化氮(INO)在AHRF治疗中的作用她还完成了几项 相关项目包括儿科AHRF中细胞因子水平的测量 INO治疗后婴儿肺功能的变化。这些经历有 增加了她对临床研究的兴趣，并导致了她扩大规模的愿望 这些技能将使她能够设计和执行有效的临床试验。 在此之前，还没有机会接受这种级别的临床培训 一直有空。UCHSC提供的设施和多比恩斯博士的经验 把她放在合适的位置进行这次训练.她近期的职业目标 是：1)熟练掌握成为一名完全训练有素的员工所需的技能 临床研究人员；以及2)使用此培训和与 有经验的临床研究人员更好地了解病理生理学和 AHRF的治疗。多比恩斯博士的长期职业目标是成为 独立的临床调查员。这一奖项将使她能够获得这些 目标通过提供：1)在严格的教学中指导学习的时间 培训计划旨在提供最佳环境和 学习机制；2)有足够的时间积累经验 临床研究中的方法和实验方法；3)结束时间 与经验丰富的导师合作；4)来自儿科GCRC的支持 为她的研究项目提供设施和人员；5)完善她的临床 随着培训的进展进行研究；以及6)作为一名 临床调查员。该提案详细说明了一项有组织的计划 将教学培训和批判性互动与经验丰富的人相结合 导师，从而使她能够实现她实现的长期目标 作为一名临床研究人员的独立性。