Characterization of Presynaptic Protein Nerve wracked

突触前蛋白神经损伤的表征

• 批准号: 6529744
• 负责人: Benjamin Arthur Eaton
• 金额: $ 4.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6529744
• 关键词: Drosophilidae; developmental genetics; developmental neurobiology; electrophysiology; gene induction /repression; gene mutation; genetically modified animals; glutamate receptor; nerve /myelin protein; neurogenetics; neuromuscular junction; protein structure function; receptor expression; synaptogenesis

DESCRIPTION (provided by applicant): In this proposal I plan to investigate the formation and function of the synaptic bouton at the Drosophila NMJ. The control of the differentiation of the synapse presynaptically is poorly understood. One manifestation of this differentiation is the formation of the synaptic bouton. Synaptic boutons are found at nearly all synapses but the formation of these varicosities as well as their function has not been addressed experimentally. Preliminary data from the novel Drosophila gene nerve-wracked suggests that this gene specifically controls the formation of boutons at the NMJ. I plan to further characterize this gene and use this reagent to investigate the formation and function of synaptic boutons.

描述（由申请人提供）：在这个提案中，我计划调查