CORE--ENDOCRINOLOGY

本中心在1430年化验尿儿茶酚胺样本。 (去甲肾上腺素和肾上腺素)和皮质醇在 项目CBSM干预后的基线和多个时间点 0002和0004。所获得的数据将检验关于 CBSM干预对适应行为挑战的有效性。这 CORE将在1636个血浆样本中检测ACTH和相同的 在本项目中获得的血浆皮质醇和儿茶酚胺的数量 基线和不同时间点的反应动力学研究 评价性演讲挑战。 此外，毒理检查(可卡因、鸦片、大麻、苯丙胺和 将对所有尿样进行酒精检测)，以便 检查研究对象遵守无药物疗法的情况 需要在计划项目中调查CBSM的有效性。 总体而言，在这个核心进行的化验将提供数据来测试 假设CBSM干预会降低交感觉醒。 此核心与所有项目交互，此外，还与 免疫学核心，检验内分泌和免疫之间的关系 接受CBSM干预的受试者的状况。

This core assays in year 1, 430 samples for urine for catecholamines (norepinephrine and epinephrine) and an identical number for cortisol at baseline and at multiple time points after CBSM intervention in Projects 0002 and 0004. The data obtained will test hypotheses regarding the efficacy of CBSM intervention in adaptation to behavioral challenge. This core will assay in year 1, 636 samples of plasma for ACTH and identical numbers for plasma cortisol and catecholamines obtained in this project at baseline and different time points to examine the kinetics of response to evaluative speech challenge. In addition, tox screens (cocaine, opiates, marijuana, amphetamine and alcohol) will be carried out on all the samples of urine in order to examine compliance of the study subjects to adhere to a drug-free regimen needed to investigate the efficacy of CBSM in the Program Project. Overall the assays carried out in this core will provide data to test the hypothesis that CBSM intervention will reduce the sympathetic arousal. This core interacts with all the projects and additionally, interacts with Immunology Core, to test a relationship between endocrines and immune status in subjects undergoing CBSM intervention.