HIV1 + IDU's--ENDOCRINE CONSEQUENCES & MEDICAL OUTCOMES

HIV1 注射吸毒者——内分泌后果

• 批准号: 6891856
• 负责人: MAHENDRA KUMAR
• 金额: $ 64.51万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891856
• 关键词: HIV infections; adrenocorticotropic hormone; anxiety; clinical research; depression; gonadotropin releasing factor; gonads; hormone regulation /control mechanism; human immunodeficiency virus 1; human subject; intravenous drug abuse; neuroendocrine system; outcomes research; psychological stressor; thyroid gland; thyrotropin releasing hormone

DESCRIPTION: (provided by applicant) This application proposes to investigate the mediating role of endocrine consequences on the occurrence of mental health outcomes that take place among HIV-1+ IDUs. Injecting drug use (IDU) is one of the major risk factors for contracting human-immunodeficiency virus, type-i, (HIV-1) infection. abnormalities in various endocrine systems develop in IDUs and HIV-1+IDUs and may be associated with number of mental health outcomes. Our earlier reports show that the ACTH and cortisol responses to a cold pressor challenge are attenuated in HIV-1 + individuals and, thus, support the proposed hypothesis. An array of outcomes including, anxiety, depression, and perceived psychological distress and difficulty adapting to stressors occurs in HIV-1 + IDUs. Since HIV is present in the brain soon after infection and esides in very high concentrations in the hippocampus, it is proposed that different endocrine systems are likely to be adversely impacted centrally in HIV-1 infection. It is important to understand the mechanisms involved in the development of neuroendocrine abnormalities - central or peripheral - in order to intervene n mental health-related problems. This five-year proposal investigates the responses of the thyroid and gonads to trophic hormones, hyroid releasing hormone (TRH), and luteinizing hormone-releasing hormone (LHRH), as well as adrenal Aictivity in response to a low-dose ACTH challenge. This investigation will be carried out using a crossectional three-group design (HIV-i+ lDUs, N+1OO, HIV-1- IDUs, N=100, and HIV-1- non-IDUs, N=100) with the total N = 300, X 3 ethnicitlies (African-Americans, Hispanics, Caucasians) X 2 genders (Women and Men). Only those HIV seropostiive subjects who do not have AIDS-defining symptoms and are not being treated with triple-drug therapy will be enrolled since the effect of triple-drug therapy on the endocrine system is unknown at this time. It is proposed to investigate whether the endocrine responses nediate mental health outcomes (i.e., depression, anxiety, and perceived psychological distress). These data will be useful in designing suitable interventions.

描述：（由申请人提供）本申请建议调查 内分泌后果对发生心理健康的中介作用 HIV-1+ IDU之间发生的结果。注射毒品使用（IDU）是 收缩人类免疫缺陷病毒的主要风险因素，I型， （HIV-1）感染。 IDU中各种内分泌系统的异常 和HIV-1+IDU，可能与心理健康成果的数量有关。我们的 较早的报告表明，ACTH和皮质醇对冷压的反应 挑战在HIV-1 +个体中受到衰减，因此支持提议 假设。一系列结果，包括焦虑，抑郁和感知 心理困扰和适应压力源的困难发生在HIV-1 +中 idus。由于感染后不久，大脑中存在艾滋病毒，并且非常 海马中的高浓度，提议不同的内分泌 系统可能会在HIV-1感染中受到不利影响。这是 了解开发的机制很重要 神经内分泌异常 - 中心或周围 - 以进行干预 与心理健康有关的问题。 该五年提案调查了甲状腺和性腺对 营养激素，杂种释放激素（TRH）和黄体生成 激素释放激素（LHRH），以及肾上腺的响应性 低剂量ACTH挑战。此调查将使用 交叉三组设计（HIV-I+ LDU，N+ 1OO，HIV-1- IDUS，N = 100， HIV-1-非伊德斯，n = 100），总n = 300，x 3 entnicitlies （非洲裔美国人，西班牙裔，高加索人）x 2性别（男女）。仅有的 那些没有艾滋病症状并且是 由于未接受三重药物治疗的治疗 目前，内分泌系统上的三重药物治疗尚不清楚。这是 提议调查内分泌反应是否适合精神健康 结果（即抑郁，焦虑和感知的心理困扰）。 这些数据对于设计合适的干预措施将很有用。

项目成果

Human immunodeficiency virus type 1 in the central nervous system leads to decreased dopamine in different regions of postmortem human brains.

• DOI: 10.1080/13550280902973952
• 发表时间: 2009-05
• 期刊: JOURNAL OF NEUROVIROLOGY
• 影响因子: 3.2
• 作者: Kumar, Adarsh M.;Fernandez, J. B.;Singer, Elyse J.;Commins, Deborah;Waldrop-Valverde, Drenna;Ownby, Raymond L.;Kumar, Mahendra
• 通讯作者: Kumar, Mahendra