CORE--CLINICAL

描述：这个核心是人类受试者进入 项目。这一核心负责对患有 疑似HD，对HD高危个体的症状前评估，以及 对HD样表型患者的评估。这一核心保持了广泛的 计算机化的数据库，在其范围、持续时间和数量上是唯一的 研究对象。这一核心包括每周一次的研究诊所，在那里，新的评估 每年都会对受试者进行跟踪。此核心还包含 纵向核心研究，检查临床人群的子集 并给予更广泛的电池和一年两次的核磁共振检查。这个核心也一直是 负责非常成功地招募临床受试者 审判。本报告的核心目标是继续评估 受影响的、处于危险中的和类HD的受试者，并将他们招募到纵向 后续，继续生成关于这些受试者的大量纵向数据 从临床前期一直到死亡，继续提供更多 纵向核心研究中对队列子集的广泛测试 (它也将作为治疗对象的主要储存库 试验)，并开发新的评估方法，特别是 对早期HD敏感并可区分症状前基因 控制中心的携带者。

DESCRIPTION: This Core serves as the point of entry for human subjects into the project. This Core is responsible for the clinical evaluations of patients with suspected HD, presymptomatic evaluations of individuals at risk for HD, and evaluation of patients with HDlike phenotypes. This Core maintains an extensive computerized database which is unique in its scope, duration, and number of subjects. This Core includes a weekly research clinic, in which new evaluations are performed, with subjects followed annually. This Core also contains the Longitudinal Core Study, in which a subset of the clinic population is examined and given a more extensive battery and a biannual MRI. This Core has also been responsible for the highly successful recruitment of subjects for clinical trials. The goals of this Core for this submission are to continue to evaluate affected, at risk, and HDlike subjects and recruit them into longitudinal followup, to continue to generate a body of longitudinal data on these subjects from the preclinical period all the way to death, to continue to provide more extensive testing on a subset of the cohort in the Longitudinal Core Study (which will also serve as the primary reservoir of subjects for therapeutic trials), and to develop new methods of assessment which are particularly sensitive to early HD and capable of distinguishing presymptomatic gene carriers from controls.