SPECT AND DEPRESSION IN ALZHEIMER'S DISEASE AND HUNTINGTON'S DISEASE

抑郁症很常见，尤其是在老年人中。它有时会 预示并经常伴随着其他疾病，如阿尔茨海默氏症 或者帕金森氏症，这些疾病在老年时更常见。抑郁症 导致严重的发病率和死亡率，特别是在 老年人，由于日常生活活动困难，病情恶化 医疗问题，以及自杀率的增加。然而，研究 脑功能成像与特发性(或内源性)的相关性 抑郁症是困难的，可能是因为临床和生物学的原因。 异质性。神经精神障碍中的抑郁，因为 神经病理学特征良好，可作为一种模型 特发性抑郁症。我们建议研究现象学和 功能性脑成像与两种抑郁症的相关性 具有良好临床症状和特征的神经精神疾病 神经病理学(阿尔茨海默病和亨廷顿病) 光子发射断层扫描(SPECT)。这样的比较研究将 解决疾病特异性神经生理学和疾病的潜在存在 抑郁症的症状特征。 阿尔茨海默病和亨廷顿病患者的抑郁与 脑血流单项检测中的特异性障碍 光子发射断层扫描。具体地说，患有AD的抑郁症患者 和HD相比，HD会有共同的下额叶低灌注率 患有这些疾病的非抑郁症患者。我们预测血液流量 异常将是症状状态的特征。 测定脑功能成像(AD)和亨廷顿氏(HD)。 我们会将抑郁和非抑郁的受试者与这些疾病进行比较 通过单光子发射断层扫描测量脑血流量 (SPECT)，并根据抑郁症、痴呆症和 功能性残疾。

Depression is common, particularly among the elderly. It sometimes heralds, and frequently accompanies, other diseases such as Alzheimer's or Parkinson's disease which are more prevalent in old age. Depression leads to significant morbidity and mortality, especially among the elderly, through difficulties with activities of daily living, worsening of medical problems, and an increased rate of suicide. However, study of the functional brain imaging correlates of idiopathic (or endogenous) depression is difficult, perhaps because of clinical and biological heterogeneity. Depression in neuropsychiatric disorders, because the neuropathology is well characterized, can serve as a model for idiopathic depression. We propose to study the phenomenology and functional brain imaging correlates of depression in two neuropsychiatric diseases with well-characterized clinical syndromes and neuropathology (Alzheimer's and Huntington's disease) using single photon emission tomography (SPECT). Such comparative studies will address the potential existence of diseasespecific neurophysiologic and symptom profiles in depression. Depression in Alzheimer's and Huntington's disease is associated with specific disturbances in cerebral blood flow as measured by single photon emission tomography. Specifically, depressed patients with AD and HD will have in common inferior frontal hypoperfusion compared to non-depressed patients with these diseases. We predict blood flow abnormalities will be characteristic of the symptomatic state. To determine the functional brain imaging (AD) and Huntington's (HD). We will compare depressed and non-depressed subjects with these diseases by measuring cerebral blood flow by single-photon emission tomography (SPECT), and evaluate patients on scales of depression, dementia, and functional disability.