Microarray Technology To Study Molecular Pathways In Dis

用于研究疾病分子途径的微阵列技术

• 批准号: 6501223
• 负责人: Raymond W Tennant
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6501223
• 关键词: AIDS; Parkinson's disease; apoptosis; biotechnology; complementary DNA; disease /disorder etiology; disease /disorder prevention /control; gene expression; genetic techniques; high throughput technology; microarray technology; molecular genetics; neoplasm /cancer; pathologic process; technology /technique development

Studies of the molecular changes that are a consequence of various disease states may ultimately lead to an understanding of the process of disease development and possible prevention of the progression of disease. We are developing cDNA microarray technology and intend to use this technology to determine mechanisms regulating apoptosis. Advances in genomics has allowed for the development of technology where gene expression of thousands of genes may be monitored simultaneously in biological samples. We are currently conducting studies examining the gene expression changes in a variety of cells exposed to apoptotic agents. These basic studies will contribute information that may be useful in the treatment and understanding of some diseases including AIDS, Parkison?s disease and cancer where apoptosis is a significant contributing component.

对各种疾病状态导致的分子变化的研究可能最终导致对疾病发展过程的理解和对疾病进展的可能预防。我们正在开发基因芯片技术，并打算利用这项技术来确定调控细胞凋亡的机制。基因组学的进步使技术的发展成为可能，可以在生物样本中同时监测数千个基因的基因表达。我们目前正在进行研究，检测暴露在凋亡剂中的各种细胞的基因表达变化。这些基础研究将有助于治疗和了解一些疾病，包括艾滋病、帕金森氏病、S病和癌症，这些疾病中细胞凋亡是一个重要的组成部分。