Antecedents of Drug Abuse and Dependence

描述：（申请人提供） 关于药物使用的研究试图了解个人、社会和 环境对药物使用开始、持续和滥用的影响， 依赖尽管研究人员已经确定了许多药物使用的预测因素 在开始时，对药物滥用的起因了解得较少， 依赖拟议研究的总体目标是检查个人， 儿童和青少年时期的社会和背景因素， 有药物滥用问题的成年人与没有这些问题的成年人。更 具体来说，这项研究将使用25年的流行病学数据， 一项来自Woodlawn的队列（n= 1240）的纵向研究，一名非裔美国人 芝加哥的一个社区。该队列在一年级（6岁）进行评估， 青少年（15-17岁）和成年（32-33岁），84%的人 原始队列纳入成人阶段。该研究将审查其影响 一年级的攻击性行为，青少年社会关系和吸毒， 在成年期滥用和依赖毒品。数据包括自 报告，教师和心理学家的评级，和母亲？报告;普查数据 将被用来检查邻里效应。使用分层 回归分析和多水平分析将允许检查两者 这些因素对成人药物滥用的直接和间接影响， 依赖

DESCRIPTION: (Provided by Applicant) Research on drug use has sought to understand the individual, social, and environmental influences on drug use initiation, continuation, and abuse and dependence. Although researchers have identified many predictors of drug use initiation, less has been learned about the antecedents of drug abuse and dependence. The overall goal of the proposed study is to examine individual, social, and contextual factors in childhood and adolescence that distinguish adults with substance abuse problems from those without such problems. More specifically, the study will use data from a 25-year epidemiological, longitudinal study of a cohort (n= 1240) from Woodlawn, an African American community in Chicago. The cohort was assessed in first grade (age 6), in adolescence (ages 15-17), and in adulthood (ages 32-33), with 84 percent of the original cohort included in the adult phase. The study will examine the impact of first grade aggressive behavior, adolescent social bonds and drug use, and neighborhood on drug abuse and dependence in adulthood. The data includes self reports, teacher and psychologist ratings, and mothers? reports; census data will be used to examine neighborhood effects. The use of hierarchical regression analyses and multi-level analyses will allow for examination of both the direct and indirect effects of these factors on adult drug abuse and dependence.