Antecedents of Drug Abuse and Dependence

药物滥用和依赖性的前因

• 批准号: 6661225
• 负责人: KATE E FOTHERGILL
• 金额: $ 3.91万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-16 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6661225
• 关键词: African American; adolescence (12-20); aggression; child behavior disorders; human data; middle childhood (6-11); predoctoral investigator; social support network; substance abuse epidemiology; substance abuse related behavior; substance abuse related disorder; young adult human (21-34)

DESCRIPTION: (Provided by Applicant) Research on drug use has sought to understand the individual, social, and environmental influences on drug use initiation, continuation, and abuse and dependence. Although researchers have identified many predictors of drug use initiation, less has been learned about the antecedents of drug abuse and dependence. The overall goal of the proposed study is to examine individual, social, and contextual factors in childhood and adolescence that distinguish adults with substance abuse problems from those without such problems. More specifically, the study will use data from a 25-year epidemiological, longitudinal study of a cohort (n= 1240) from Woodlawn, an African American community in Chicago. The cohort was assessed in first grade (age 6), in adolescence (ages 15-17), and in adulthood (ages 32-33), with 84 percent of the original cohort included in the adult phase. The study will examine the impact of first grade aggressive behavior, adolescent social bonds and drug use, and neighborhood on drug abuse and dependence in adulthood. The data includes self reports, teacher and psychologist ratings, and mothers? reports; census data will be used to examine neighborhood effects. The use of hierarchical regression analyses and multi-level analyses will allow for examination of both the direct and indirect effects of these factors on adult drug abuse and dependence.

描述：(申请人提供) 对药物使用的研究试图了解个人、社会和 环境对药物使用开始、持续和滥用的影响以及 依赖。尽管研究人员已经确定了许多药物使用的预测因素 在启蒙阶段，对药物滥用的前驱和 依赖。拟议研究的总体目标是检查个人， 儿童和青春期的社会和背景因素 有药物滥用问题的成年人与没有药物滥用问题的成年人不同。更多 具体地说，这项研究将使用25年来流行病学、 非裔美国人伍德劳恩队列(n=1240)的纵向研究 芝加哥的社区。队列评估是在一年级(6岁)进行的， 青春期(15-17岁)和成年期(32-33岁)，84%的人 成人阶段的原始队列包括在内。这项研究将考察其影响 一年级攻击性行为、青少年社会纽带和吸毒，以及 关于成年后吸毒和依赖的邻里关系。该数据包括自身 报告，教师和心理学家的评分，还有母亲？报告；人口普查数据 将被用来检查邻里效应。层次化的使用 回归分析和多水平分析将允许对两者进行检查 这些因素对成人药物滥用的直接和间接影响 依赖。