Hearing in Belgian Waterslager Canaries

比利时 Waterslager Canaries 听证会

• 批准号: 6552293
• 负责人: Amanda M. Lauer
• 金额: $ 2.89万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6552293
• 关键词: auditory threshold; behavior test; cochlear lesion; ear hair cell; hearing disorders; operant conditionings; psychoacoustics; regeneration; scanning electron microscopy; sensorineural hearing loss; songbirds; sound frequency; sound perception; vocalization

DESCRIPTION (provided by applicant): The main goal of the proposed research is to provide a more complete assessment of hearing in the Belgian Waterslager canary. This strain of canary has a hereditary hearing loss associated with missing and damaged hair cells. Little is known about how these hair cell abnormalities affect hearing, other than elevating pure tone thresholds, particularly at high frequencies. In the present study, psychoacoustic methods will be used to investigate hearing abilities in Belgian Waterslager and normal hearing canaries. In a series of behavioral experiments, I will assess frequency analysis, temporal processing, and perception of vocalizations. The performance of Belgian Waterslager canaries on these tasks will be compared to the performance of normal hearing canaries. In addition, I will investigate the behavioral effects of hair cell damage and regeneration after noise exposure in these birds, followed by an anatomical study of the basilar papillae. What makes canaries especially interesting subjects for hearing experiments is that they have been used in many behavioral and neurobiological studies of vocal learning and neurogenesis. Thus, the proposed experiments will increase our understanding of the functional consequences of hearing impairment in these birds, and of hearing impairment in general.

描述（由申请人提供）：拟议研究的主要目标是对比利时沃特斯拉格金丝雀的听力进行更全面的评估。这种金丝雀有一种遗传性听力损失，与毛细胞缺失和受损有关。关于这些毛细胞异常如何影响听力，除了提高纯音阈值，特别是在高频下，我们知之甚少。在本研究中，心理声学方法将被用来调查听力在比利时沃特斯拉格和正常听力金丝雀的能力。在一系列的行为实验中，我将评估频率分析，时间处理和感知的发声。比利时Waterslager金丝雀在这些任务上的表现将与正常听力金丝雀的表现进行比较。此外，我将调查的行为影响毛细胞损伤和再生后，噪音暴露在这些鸟类，其次是解剖学研究的基底乳头。金丝雀之所以成为听力实验的对象，是因为它们被用于许多关于发声学习和神经发生的行为和神经生物学研究。因此，拟议的实验将增加我们对这些鸟类听力障碍的功能后果以及一般听力障碍的理解。