Hearing in Belgian Waterslager Canaries

比利时 Waterslager Canaries 听证会

• 批准号: 6640560
• 负责人: Amanda M. Lauer
• 金额: $ 3.07万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640560
• 关键词: auditory threshold; behavior test; cochlear lesion; ear hair cell; hearing disorders; operant conditionings; psychoacoustics; regeneration; scanning electron microscopy; sensorineural hearing loss; songbirds; sound frequency; sound perception; vocalization

DESCRIPTION (provided by applicant): The main goal of the proposed research is to provide a more complete assessment of hearing in the Belgian Waterslager canary. This strain of canary has a hereditary hearing loss associated with missing and damaged hair cells. Little is known about how these hair cell abnormalities affect hearing, other than elevating pure tone thresholds, particularly at high frequencies. In the present study, psychoacoustic methods will be used to investigate hearing abilities in Belgian Waterslager and normal hearing canaries. In a series of behavioral experiments, I will assess frequency analysis, temporal processing, and perception of vocalizations. The performance of Belgian Waterslager canaries on these tasks will be compared to the performance of normal hearing canaries. In addition, I will investigate the behavioral effects of hair cell damage and regeneration after noise exposure in these birds, followed by an anatomical study of the basilar papillae. What makes canaries especially interesting subjects for hearing experiments is that they have been used in many behavioral and neurobiological studies of vocal learning and neurogenesis. Thus, the proposed experiments will increase our understanding of the functional consequences of hearing impairment in these birds, and of hearing impairment in general.

描述（由申请人提供）：拟议研究的主要目标是对比利时 Waterslager 金丝雀的听力进行更完整的评估。这种金丝雀品种患有与毛细胞缺失和受损有关的遗传性听力损失。除了提高纯音阈值（尤其是高频阈值）之外，人们对这些毛细胞异常如何影响听力知之甚少。在本研究中，将使用心理声学方法来调查比利时 Waterslager 和正常听力金丝雀的听力能力。在一系列行为实验中，我将评估频率分析、时间处理和发声感知。比利时 Waterslager 金丝雀在这些任务上的表现将与正常听力金丝雀的表现进行比较。此外，我将研究这些鸟类暴露于噪音后毛细胞损伤和再生的行为影响，然后对基底乳头进行解剖学研究。金丝雀对听力实验特别感兴趣的原因是它们已被用于声音学习和神经发生的许多行为和神经生物学研究中。因此，所提出的实验将增加我们对这些鸟类听力损伤以及一般听力损伤的功能后果的理解。