Photochemical Approaches to Cyclobutane Functionalization and Cyclopropane Cascade Reactions

环丁烷官能化和环丙烷级联反应的光化学方法

• 批准号: 2056622
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2056622
• 关键词: Photochemical; Approaches; Cyclobutane; Functionalization; Cyclopropane

This project will investigate the formation and further reactions of small ring systems.For example maleic anhydride derivatives will be investigated in a variety of [2+2] cycloaddition reactions with a range of alkynes. These cyclobutenes will then be investigated as scaffolds for further elaboration as drug discovery libraries in collaboration with UCB. In a related study amino-cyclopropane derivatives will be investigated as substrates to undergo novel radical cyclisation cascade reactions to generate a range of complex scaffolds as possible drug discovery scaffolds.

本项目将研究小环体系的形成和进一步的反应，例如马来酸酐衍生物将与一系列炔进行各种[2+2]环加成反应。然后将这些环丁烯作为支架进行研究，以进一步与UCB合作开发药物发现库。在一项相关研究中，将研究氨基环丙烷衍生物作为底物进行新型自由基环化级联反应，以产生一系列复杂的支架作为可能的药物发现支架。