A Molecular Motor

分子马达

• 批准号: 6525401
• 负责人: T. ROSS KELLY
• 金额: $ 28.92万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6525401
• 关键词: aminopyridines; bioengineering /biomedical engineering; biomechanics; biomimetics; carbamates; catalyst; chemical cleavage; chemical kinetics; chemical structure function; chemical synthesis; hydrolysis; infrared spectrometry; intermolecular interaction; ketones; metal complex; model design /development; molecular dynamics; nanotechnology; nuclear magnetic resonance spectroscopy; physical model; quinones; technology /technique development; thermodynamics

DESCRIPTION (provided by applicant): Motion is central and essential - to life. During the past several decades enormous effort has been invested in attempting to learn how biological motors - such as muscles, flagella and cilia - operate. But even now there is little understanding, at least at the atomic level of detail, how chemically powered motors achieve directed motion. We now propose to construct a rationally designed molecular motor that may provide some insight into how biological - and other - molecular scale motors work. The motor operates as a single molecule and is powered by coupling unidirectional molecular movement with the energy released in the hydrolysis of phosgene to carbon dioxide and HCI. In the initial period of this project we achieved two functioning prototypes of the first non-natural, chemically powered molecular motor. We now propose to complete the task by elaborating the prototypes into fully operational, continuously rotating systems. The project will entail synthesis and evaluation at several levels of complexity, building on the knowledge gained from the work with the prototypes and culminating in a fully functioning version, with feedback at each step serving to refine the design of the next stage. The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems.

描述(由申请人提供)：运动是生活的中心和基本要素。 在过去的几十年里，人们投入了巨大的努力来尝试 了解生物马达--如肌肉、鞭毛和纤毛--是如何运作的。 但即使是现在，也几乎没有人理解，至少在原子水平上是这样 详细介绍化学动力马达如何实现定向运动。 我们现在提议构建一种合理设计的分子马达，它可以 提供一些关于生物和其他分子规模的马达如何 工作。该马达以单分子形式运行，并由联轴器提供动力。 分子的单向运动和在水解液中释放的能量 光气转化为二氧化碳和氯化氢。在这个项目的初期，我们 实现了第一个非天然的、化学的、具有功能的两个原型 动力分子马达。我们现在建议通过详细阐述 将原型转化为完全可操作的、连续旋转的系统。 该项目将在几个层面上进行综合和评估 复杂性，建立在从原型工作中获得的知识之上 并最终形成一个功能齐全的版本，每一步都有反馈 用来改进下一阶段的设计。 该项目应扩大对化学导向和 受控运动，这是理解 生物系统。