MOLECULAR MOTOR

描述：运动是生活的中心和基本要素。在过去 几十年来，人们投入了巨大的努力，试图了解 肌肉、鞭毛和纤毛等生物马达运作。但即使是现在 人们几乎不了解，至少在原子级别的细节上， 化学动力马达可实现定向运动。 PI现在提议构建一种分子马达，可能会提供一些 深入了解生物和其他分子规模的发动机是如何工作的。这个 马达将作为单个分子运行，并由耦合提供动力 分子的单向运动及其在水解过程中释放的能量 光气转化为二氧化碳和盐酸。 该项目将在几个层面上进行综合和评估 复杂性，从原则性阶段的论证开始，到最后 在一个功能齐全的版本中，每一步的反馈都用于改进 下一阶段的设计。 该项目应扩大对化学导向和 受控运动，这是理解 生物系统。

DESCRIPTION: Motion is central and essential to life. During the past several decades enormous effort has been invested in attempting to learn how biological motors such as muscles, flagella and cilia operate. But even now there is little understanding, at least at the atomic level of detail, how chemically powered motors achieve directed motion. The PI now proposes to construct a molecular motor that may provide some insight into how biological and other molecular scaled motors work. The motor will operate as a single molecule and is powered by coupling unidirectional molecular movement with the energy released in the hydrolysis of phosgene to carbon dioxide and HCl. The project will entail synthesis and evaluation at several levels of complexity, starting with a demonstration of principle stage and culminating in a fully functioning version, with feedback at each step serving to refine the design of the next stage. The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems.