MOLECULAR MOTOR

分子马达

• 批准号: 6181241
• 负责人: T. ROSS KELLY
• 金额: $ 18.67万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181241
• 关键词: chemical models; chemical synthesis; cytoskeletal proteins; intermolecular interaction; model design /development; molecular dynamics; nanotechnology; protein structure function

DESCRIPTION: Motion is central and essential to life. During the past several decades enormous effort has been invested in attempting to learn how biological motors such as muscles, flagella and cilia operate. But even now there is little understanding, at least at the atomic level of detail, how chemically powered motors achieve directed motion. The PI now proposes to construct a molecular motor that may provide some insight into how biological and other molecular scaled motors work. The motor will operate as a single molecule and is powered by coupling unidirectional molecular movement with the energy released in the hydrolysis of phosgene to carbon dioxide and HCl. The project will entail synthesis and evaluation at several levels of complexity, starting with a demonstration of principle stage and culminating in a fully functioning version, with feedback at each step serving to refine the design of the next stage. The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems.

描述：运动是生命的核心和必要条件。 在过去 几十年来，人们投入了巨大的努力，试图了解如何 诸如肌肉、鞭毛和纤毛的生物马达起作用。 但即使是现在 至少在原子层次的细节上， 化学动力马达实现定向运动。 PI现在建议构建一种分子马达， 深入了解生物和其他分子尺度的马达如何工作。 的 马达将作为单个分子运行，并通过耦合提供动力 在水解过程中释放能量的单向分子运动 光气转化为二氧化碳和HCl。 该项目将在若干层面上进行综合和评价， 复杂性，从原理演示阶段开始， 在一个功能齐全的版本中，每一步的反馈都有助于改进 下一阶段的设计。 该项目应扩大对化学定向和 控制运动，这是一个主题的核心理解， 生物系统。