Hybrid Enzymatic-Heterogeneous Catalytic Systems for Fine Chemical Synthesis

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Enzymatic hydrogenation usually requires cofactors, e.g. NADH, as hydrogen donors. Regarding process sustainability, regeneration of cofactor is essential. Conventional methods using a second enzyme increase the complexity of the system and the downstream product separation and purification. In this project, regeneration of cofactor via heterogeneous catalysis will be tested. A combined system with immobilised enzyme will also be examined. Several enzymatic-heterogeneous catalytic systems will be developed to target fine chemical synthesis.