Hybrid Enzymatic-Heterogeneous Catalytic Systems for Fine Chemical Synthesis

用于精细化学品合成的混合酶多相催化系统

• 批准号: 2065950
• 金额: --
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2065950
• 关键词: Hybrid; Enzymatic; Heterogeneous; Catalytic; Systems

Enzymatic hydrogenation usually requires cofactors, e.g. NADH, as hydrogen donors. Regarding process sustainability, regeneration of cofactor is essential. Conventional methods using a second enzyme increase the complexity of the system and the downstream product separation and purification. In this project, regeneration of cofactor via heterogeneous catalysis will be tested. A combined system with immobilised enzyme will also be examined. Several enzymatic-heterogeneous catalytic systems will be developed to target fine chemical synthesis.

酶促氢化通常需要辅因子，如NADH作为供氢体。关于过程的可持续性，辅因子的再生是必不可少的。传统的方法使用二次酶，增加了系统的复杂性和下游产物的分离纯化。在本项目中，将对多相催化再生辅因子进行试验。还将研究具有固定化酶的组合系统。针对精细化学合成，将开发几种酶-多相催化体系。