CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESS

咖啡因对运动和心理压力的影响

• 批准号: 6536839
• 负责人: William R Lovallo
• 金额: $ 42.93万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536839
• 关键词: age difference; behavioral /social science research tag; blood pressure; caffeine; cardiovascular function; cardiovascular stress test; clinical research; cortisol; dosage; echocardiography; exercise; female; gender difference; human middle age (35-64); human subject; hypertension; menopause; neuroendocrine system; pharmacokinetics; physiologic stressor; psychological stressor; psychomotor function; psychopharmacology

Description (adapted from the investigator's abstract): Understanding caffeine's effects in persons as they age is critical to our understanding of how caffeine affects health. This project will examine caffeine effects in 210 men and women in early (35-49 years) vs. late (50-64 years) middle age, with a secondary emphasis on variations in response as women enter menopause, a time of increased risk of heart disease and hypertension. Caffeine is widely used in significant quantities. Caffeine affects the central nervous system, cardiovascular activity, and endocrine function, and intake may increase during times of stress. Caffeine increases cardiovascular disease risk factors such as serum cholesterol and lipids. Accordingly, in a randomized crossover trial, men and women will be placed on each of two levels of caffeine intake (0 mg/day vs. 240 mg/day) for 6 days each, ending with 24-hr ambulatory monitoring of blood pressure and cortisol. Laboratory testing on day 7 will establish the effect of acute doses (200 mg x 2) on responses to mental and exercise stress. The project has 3 hypotheses: First, caffeine elevates blood pressure and cortisol secretion even with daily consumption. Second, these effects are enhanced during mental and exercise stress. Third, the effects increase from early to late middle age. It is anticipated that caffeine effects will be prominent in postmenopausal women not on estrogen replacement. Cardiovascular variables are blood pressure and hemodynamic and cardiodynamic measures taken using impedance cardiography and echocardiography. The target neuroendocrine variable will be cortisol because it is the central component of the response to stress and is responsive to caffeine. Modest elevations over long periods are thought to alter immune system function and to affect the aging process. A recent study shows that caffeine increases cortisol in the evening hours, disturbing its normal diurnal cycle. This new information should aid in evaluating caffeine's effects over the span of midlife, a time at which the cardiovascular health of women changes markedly relative to men.

描述（改编自研究者摘要）：理解 咖啡因对人衰老的影响对我们理解 咖啡因如何影响健康该项目将在210年检查咖啡因的影响 男性和女性在中年早期（35-49岁）与中年晚期（50-64岁）， 第二个重点是随着女性进入更年期， 心脏病和高血压的风险增加。咖啡因被广泛用于 数量可观。咖啡因影响中枢神经系统， 心血管活动和内分泌功能，摄入量可能会增加， 压力的时候。咖啡因会增加心血管疾病的危险因素，例如 血清胆固醇和脂质。因此，在一项随机交叉试验中， 女性将被置于两个咖啡因摄入水平（0毫克/天vs. 240 mg/天），每次6天，结束时进行24小时动态血液监测 压力和皮质醇第7天的实验室检测将确定 急性剂量（200 mg x 2）对精神和运动应激反应的影响。的 该项目有三个假设：首先，咖啡因会升高血压和皮质醇 即使是日常消费。第二，这些效果增强 在精神和运动压力下。第三，从早期到晚期， 中年晚期预计咖啡因的作用将在 绝经后未服用雌激素替代品的女性心血管变量是 使用阻抗进行血压和血液动力学和心脏动力学测量 心脏描记术和超声心动图。目标神经内分泌变量将是 皮质醇，因为它是对压力反应的核心成分， 对咖啡因敏感人们认为，长期的适度海拔 改变免疫系统功能，影响衰老过程。最近的一项研究 表明咖啡因会在晚上增加皮质醇，扰乱大脑 正常的昼夜循环这一新的信息应该有助于评估咖啡因的 在中年的跨度，在这个时候，心血管健康的影响， 妇女相对于男子变化显著。