ULTRASOUND-INDUCED LUNG DAMAGE ASSESSMENT

描述（由申请人提供）：拟议的研究计划是一个基本的 已知超声诱导生物学的科学（非临床）评价 影响，其目标是确定当前和未来的作用， 诊断超声相对于这种生物效应。医疗 如果显示诊断超声是一种重要的 通过告知临床医生该风险，对患者造成医疗风险，以及 提示临床医生如何监测风险程度。同样， 如果显示诊断超声不是一种 通过消除这一临床风险， 关心无论哪种情况，都有明显的医学意义。数据 目前没有必要决定这个问题。现状 关于实验动物中超声波引起的肺损伤， 认为超声诊断设备对人类构成风险。 拟议的研究旨在通过一项 跨学科的研究小组，他们有相当多的实验 超声诱导肺损伤、肺形态学和肺 功能研究，此外，相当多的实验和 具有超声生物物理学和相关物理学领域的理论经验。 实验（基于动物）和理论（机制开发） 研究计划有四个具体目标，即，(1)来评估超声波 发生最小可检测肺出血的水平， 物种和年龄;（2）评估生理分支和功能， (3)通过实验评估损伤机制;（4）开发一个 一种针对一类损伤机制的理论。实验 设计研究了超声诱导的肺出血， 年龄和物种，以及实验变量的设计都旨在 提供了一个数据库，可以用来推断人类的发现， 生物。这些理论研究为理解 的基本机制，以便另一种方法可用于外推， 人类

DESCRIPTION (Provided by Applicant): The proposed research program is a basic science (non-clinical) evaluation of a known ultrasound-induced biological effect, the goal of which is to determine the current and future role of diagnostic ultrasound relative to this biological effect. The medical profession benefits if it is shown that diagnostic ultrasound is a significant medical risk to the patient by advising clinicians about this risk, and suggesting how the clinician can monitor the degree of risk. Likewise, the medical profession benefits if it is shown that diagnostic ultrasound is not a significant medical risk to the patient by eliminating this as a clinical concern. In either case, there is clear medical significance. The data necessary to decide this issue are not currently available. The current status regarding ultrasound-induced lung damage in experimental animals supports the view that diagnostic ultrasound equipment poses a risk to human beings. The proposed studies have been designed to address directly these issues by an interdisciplinary group of investigators who have considerable experimental experience with ultrasound-induced lung damage, lung morphology and lung function research studies, and in addition considerable experimental and theoretical experience with ultrasound biophysics and related physics areas. The experimental (animal-based) and theoretical (mechanism-development) research program has four specific aims, viz., (1) to evaluate ultrasound levels at which minimum detectable lung hemorrhage occurs as a function of species and age; (2) to evaluate the physiological ramifications and function, (3) to evaluate the damage mechanism experimentally; and (4) to develop a theory that addresses one general class of damage mechanisms. The experimental design investigates ultrasound-induced lung hemorrhage as a function of both age and species, and the design of the experimental variables all aim at providing a database that can be used to extrapolate the findings to human beings. The theoretical studies provide a mathematical basis for understanding the basic mechanism so that another approach is available for extrapolating to humans.