Coronary Vasa Vasorum - Role of 3D Branching Geometry
Coronary Vasa Vasorum - Role of 3D Branching Geometry
批准号:
6537854
负责人:
Erik Leo Ritman
金额:
$34.64万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2005-03-31
关键词:
anatomy atherosclerosis biological fluid transport biomechanics blood circulation blood pressure blood vessels computed axial tomography contrast media coronary artery cryoscience disease /disorder model hemodynamics histology hypercholesterolemia hypertension solute swine vascular endothelium vascular endothelium permeability
中文摘要
描述(逐字摘自申请人摘要):本次重新提交
由三个相互重叠的目标按时间顺序排列组成,
总的假设是,血管在
冠状动脉粥样硬化形成的开始(即,在细胞侵入之前和/或
增殖)通过经血管的溶质转运紊乱
这反过来又是由于他们远端血管的灌注压
管腔小于动脉壁中的压缩。我们的做法是
定量描述详细的分支几何形状和溶质运输的
冠状动脉的血管,主要通过使用基于微CT的成像
方法.这将涉及正常猪的冠状动脉分析,
猪(饮食诱导)高胆固醇血症模型和猪(肾)
动脉支架)模型的动脉高血压(两者都是风险因素,
动脉粥样硬化)。AIM I是用于初始开发和整合
我们建议在整个提案中使用的各种技术,
正常状态。目标二将目标一的发展应用于
高胆固醇血症和高血压猪的冠状动脉壁,
将血管的反应与这些病理状况联系起来。目的
III建立在目标II的基础上,我们将联合收割机结合高胆固醇血症和
高血压,看看他们是否是线性相加的效果,因为将
根据我们的假设。主要目标是将运输
血管容积对冠状动脉血管空间密度的影响
和流体动力学的影响,这两个三维分支几何形状的
血管内压应力的空间分布
冠状动脉壁这项建议的意义在于,如果
这项研究的假设是支持的,它应该提供洞察几个
令人困惑的观察一个是动脉粥样硬化通常不会在
静脉(有血管)或小动脉(无血管)
vasorum)。同样有趣的是早期动脉粥样硬化的观察结果,
即使血管壁提供了一个
相当大的内皮表面(推测也变得功能障碍),
外中膜和外膜。另一个观察是,
外膜被操纵,静脉受到动脉压力
或手术操作,会发展成动脉粥样硬化。
英文摘要
DESCRIPTION (Verbatim from the Applicant's Abstract): This resubmission
consists of a chronological sequence of three overlapping aims which test the
overall hypothesis that the vasa vasorum play an important role in the
initiation of coronary atherogenesis (i.e., prior to cellular invasion and/or
proliferation) by virtue of disturbed solute transport via the vasa vasorum
This, in turn, is due to the perfusion pressure in their distal vasa vasorum
lumens being less than the compression in the arterial wall. Our approach is to
quantitatively describe detailed branching geometry and solute transport of the
vasa vasorum of coronary arteries, primarily by use of micro-CT-based imaging
methods. This will involve analysis of coronary arteries of normal pigs, a
porcine (diet-induced) model of hypercholesterolemia and a porcine (renal
artery stent) model of arterial hypertension (both being risk factors for
atherogenesis). AIM I is for the initial development and integration of the
various techniques we propose to use throughout the proposal and to establish
the normal state. AIM II applies the developments in Aim I to
hypercholesterlemic and to hypertensive pigs' coronary artery walls so as to
relate the response of the vasa vasorum to these pathological conditions. AIM
III builds on Aim II in that we will combine the hypercholesterolemia and
hypertension to see if they are linearly additive in effect, as would be
predicted by our hypothesis. The primary objective is to relate the transport
capacity of vasa vasorum to the spatial density of coronary artery vasa vasorum
and the fluid dynamic implications of both the 3D branching geometry of the
vasa vasorum and the spatial distribution of compressive stresses within the
coronary artenal wall. The significance of this proposal is that if the
hypothesis of this study is supported, it should give insight into several
puzzling observations. One is that atherosclerosis does not generally form in
veins (which have vasa vasorum) or in small arteries (which have no vasa
vasorum). Equally intriguing is the observation that early atherosclerosis does
not form in the outer media or adventitia even though vasa vasorum provide a
sizable endothelial surface (which presumably also becomes dysfunctional) in
the outer media and adventitia. Another observation is that artenes whose
adventitia are manipulated and veins, which are subjected to arterial pressure
or surgically manipulated, do develop atherosclerosis.
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会议论文
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批准号:8604416
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财政年份:2013
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CT Method Development for Quantifying Myocardial Microvascular Flow Distribution
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财政年份:2003
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:7894700
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资助金额:$33.6万
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:6830768
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资助金额:$36.88万
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:6724049
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资助金额:$36.88万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:7513647
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项目类别:
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资助金额:$33.2万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:6970899
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资助金额:$36.01万
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负责人:Erik Leo Ritman
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依托单位:
Coronary Vasa Vasorum - Role of 3D Branching Geometry
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批准号:7568777
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资助金额:$40.58万
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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资助金额:$35.03万
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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REGIONAL MYOCARDIAL FLOW MEASUREMENT BY XRAY COMPUTED TOMOGRAPHY
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DEDICATED COMPUTER FOR RECONSTRUCTING MICRO-CT 3D IMAGES
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REGIONAL MYOCARDIAL FLOW MEASUREMENT BY XRAY COMPUTED TOMOGRAPHY
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CT ANALYSIS OF MYOCARDIAL MICROCIRCULATORY FUNCTION
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海外基金