Coronary Vasa Vasorum - Role of 3D Branching Geometry
Coronary Vasa Vasorum - Role of 3D Branching Geometry
批准号:
6537854
负责人:
Erik Leo Ritman
金额:
$34.64万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2005-03-31
关键词:
anatomy atherosclerosis biological fluid transport biomechanics blood circulation blood pressure blood vessels computed axial tomography contrast media coronary artery cryoscience disease /disorder model hemodynamics histology hypercholesterolemia hypertension solute swine vascular endothelium vascular endothelium permeability
中文摘要
描述(逐字摘自申请者摘要):此重新提交
由三个重叠的目标按时间顺序组成,这些目标测试
全面的假设认为,血管在脑出血中起重要作用
冠状动脉粥样硬化的启动(即,在细胞入侵和/或
增殖)通过血管被扰乱的溶质运输
这又是由于血管远端血管的灌流压力所致。
管腔小于动脉壁内的压力。我们的方法是
定量地描述了详细的分支几何形状和溶质运移
冠状动脉的血管迷走神经,主要是利用基于显微CT的成像
方法:研究方法。这将包括对正常猪的冠状动脉进行分析,
猪(饮食诱导)高胆固醇血症模型和猪(肾)模型
动脉支架)模型(两者都是高血压的危险因素
动脉粥样硬化)。目标I是为了初步开发和集成
我们建议在整个提案中使用的各种技术,并建立
正常状态。AIM II将AIM I中的发展应用于
高胆固醇血症和高血压猪的冠脉壁
将血管对这些病理情况的反应联系起来。目标
III建立在AIM II的基础上,我们将结合高胆固醇血症和
高血压,看看它们是否是线性相加的效果,
根据我们的假设预测。主要目标是将运输与
血管容量对冠状动脉血管空间密度的影响
以及三维分支几何结构的流体动力学含义
血管内压应力的空间分布
冠状动脉壁。这项提议的意义在于,如果
这项研究的假设得到支持,它应该能洞察到几个
令人费解的观察。其一是动脉粥样硬化通常不会形成于
静脉(有血管)或小动脉(没有血管)
血管)。同样耐人寻味的是观察到早期动脉粥样硬化
不在外中膜或外膜形成,即使血管提供了
相当大的内皮表面(据推测也会变得功能失调)
外膜和外膜。另一种观察是,阿特宁的
外膜受到操纵,静脉受到动脉压力的影响。
或通过手术操作,确实会发展成动脉粥样硬化。
英文摘要
DESCRIPTION (Verbatim from the Applicant's Abstract): This resubmission
consists of a chronological sequence of three overlapping aims which test the
overall hypothesis that the vasa vasorum play an important role in the
initiation of coronary atherogenesis (i.e., prior to cellular invasion and/or
proliferation) by virtue of disturbed solute transport via the vasa vasorum
This, in turn, is due to the perfusion pressure in their distal vasa vasorum
lumens being less than the compression in the arterial wall. Our approach is to
quantitatively describe detailed branching geometry and solute transport of the
vasa vasorum of coronary arteries, primarily by use of micro-CT-based imaging
methods. This will involve analysis of coronary arteries of normal pigs, a
porcine (diet-induced) model of hypercholesterolemia and a porcine (renal
artery stent) model of arterial hypertension (both being risk factors for
atherogenesis). AIM I is for the initial development and integration of the
various techniques we propose to use throughout the proposal and to establish
the normal state. AIM II applies the developments in Aim I to
hypercholesterlemic and to hypertensive pigs' coronary artery walls so as to
relate the response of the vasa vasorum to these pathological conditions. AIM
III builds on Aim II in that we will combine the hypercholesterolemia and
hypertension to see if they are linearly additive in effect, as would be
predicted by our hypothesis. The primary objective is to relate the transport
capacity of vasa vasorum to the spatial density of coronary artery vasa vasorum
and the fluid dynamic implications of both the 3D branching geometry of the
vasa vasorum and the spatial distribution of compressive stresses within the
coronary artenal wall. The significance of this proposal is that if the
hypothesis of this study is supported, it should give insight into several
puzzling observations. One is that atherosclerosis does not generally form in
veins (which have vasa vasorum) or in small arteries (which have no vasa
vasorum). Equally intriguing is the observation that early atherosclerosis does
not form in the outer media or adventitia even though vasa vasorum provide a
sizable endothelial surface (which presumably also becomes dysfunctional) in
the outer media and adventitia. Another observation is that artenes whose
adventitia are manipulated and veins, which are subjected to arterial pressure
or surgically manipulated, do develop atherosclerosis.
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批准号:8604416
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资助金额:$18.54万
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财政年份:2013
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CT Method Development for Quantifying Myocardial Microvascular Flow Distribution
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批准号:8425620
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In Vivo Myocardial Microcirculatory Function
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批准号:7148064
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资助金额:$34.96万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:7894700
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资助金额:$33.6万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:6830768
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资助金额:$36.88万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:6724049
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项目类别:
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资助金额:$36.88万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:7513647
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项目类别:
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资助金额:$33.2万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
In Vivo Myocardial Microcirculatory Function
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批准号:6970899
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项目类别:
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资助金额:$36.01万
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财政年份:2003
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负责人:Erik Leo Ritman
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依托单位:
Coronary Vasa Vasorum - Role of 3D Branching Geometry
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批准号:7568777
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资助金额:$40.58万
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负责人:Erik Leo Ritman
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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批准号:6638676
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资助金额:$35.03万
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负责人:Erik Leo Ritman
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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批准号:7342778
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资助金额:$37.8万
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负责人:Erik Leo Ritman
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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资助金额:$30.8万
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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资助金额:$35.26万
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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财政年份:2000
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Coronary Vasa Vasorum - Role of 3D Branching Geometry
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REGIONAL MYOCARDIAL FLOW MEASUREMENT BY XRAY COMPUTED TOMOGRAPHY
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负责人:Erik Leo Ritman
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DEDICATED COMPUTER FOR RECONSTRUCTING MICRO-CT 3D IMAGES
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REGIONAL MYOCARDIAL FLOW MEASUREMENT BY XRAY COMPUTED TOMOGRAPHY
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负责人:Erik Leo Ritman
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CT ANALYSIS OF MYOCARDIAL MICROCIRCULATORY FUNCTION
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批准号:6319675
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项目类别:
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资助金额:$0.34万
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财政年份:1998
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海外基金