VALIDATION OF SCHOOL BASED ASTHMA SCREENING PROGRAM

学校哮喘筛查计划的验证

基本信息

批准号：
6527555
负责人：
WILLIAM C BAILEY
金额：
$ 35.88万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-30 至 2003-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6527555
关键词：
asthma clinical research diagnosis design /evaluation disease /disorder prevention /control elementary school health behavior human subject mass screening middle childhood (6-11) questionnaires spirometry

项目摘要

Asthma in children is often under-diagnosed which can be a serious problem since delays in the initiation of therapy is deleterious. Despite recent increases in asthma prevalence and morbidity in children, especially African American children, valid and reliable asthma screening measures have not been developed. Most asthma screening programs rely solely on responses to symptoms questionnaires. These programs identify large numbers of children as "possible asthma" who do not truly have the disease. The University of Alabama at Birmingham (UAB) School Based Asthma Screening Program overcomes this disadvantage by using a multi-stage screening procedure composed of a questionnaire, baseline spirometry, and an exercise challenge test. Previous research in our UAB School Based Asthma Intervention Study (funded by NHLBI) has shown that screening for asthma in a predominantly African American elementary school population can identify previously undiagnosed cases of asthma. These data show that 20 percent of asthmatics in this population were undiagnosed prior to the screening procedure, indicating a substantial burden of undiagnosed asthma in children. The primary aim of this project is to calculate the sensitivity and specificity of the UAB multi-stage asthma screening procedure. Several secondary aims will also be accomplished. These aims are: to refine the asthma symptoms questionnaire by identifying questions most predictive of an asthma diagnosis; and to determine the effect of respondent (parent or child) on reports of asthma symptoms. The validation of a simple, field-based asthma screening program will be a valuable tool in the identification of children with asthma. Such screening procedures can lead to decreases in asthma morbidity and mortality by identifying children with undiagnosed asthma.

儿童哮喘通常被诊断出来，这可能是一个严重的问题，因为启动治疗的延迟是有害的。尽管最近尚未制定有效和可靠的哮喘筛查措施的儿童哮喘患病率和发病率的升高。大多数哮喘筛查计划仅依赖于对症状问卷的回答。这些计划将大量儿童视为没有真正患病的“可能的哮喘”。伯明翰大学（UAB）学校的哮喘筛查计划的阿拉巴马大学通过使用由问卷，基线肺活量测定法和运动挑战测试组成的多阶段筛查程序来克服这一缺点。在我们的基于UAB学校的哮喘干预研究（由NHLBI资助）中的先前研究表明，在主要是非裔美国小学人口中哮喘的筛查可以识别以前未诊断的哮喘病例。这些数据表明，在筛查程序之前，该人群中有20％的哮喘患者未诊断，这表明儿童中未诊断出哮喘的负担很大。该项目的主要目的是计算UAB多阶段哮喘筛查程序的灵敏度和特异性。还将实现几个次要目标。这些目的是：通过确定最可预测哮喘诊断的问题来完善哮喘症状问卷；并确定受访者（父母或子女）对哮喘症状报告的影响。对基于现场的哮喘筛查计划的验证将是鉴定哮喘儿童的宝贵工具。这种筛查程序可以通过识别未诊断哮喘的儿童来导致哮喘发病率和死亡率降低。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Validation of a multistage asthma case-detection procedure for elementary school children.

针对小学生的多阶段哮喘病例检测程序的验证。

DOI：
10.1542/peds.2004-0455
发表时间：
2004
期刊：
Pediatrics
影响因子：
8
作者：
Gerald,LynnB;Grad,Roni;Turner-Henson,Anne;Hains,Coralie;Tang,Shenghui;Feinstein,Ronald;Wille,Keith;Erwin,Sue;Bailey,WilliamC
通讯作者：
Bailey,WilliamC

Asthma morbidity among children evaluated by asthma case detection.

通过哮喘病例检测评估儿童哮喘发病率。