GLUCOCORTICOIDS AND CENTRAL FETAL VASOMOTOR CONTROL

糖皮质激素和中枢胎儿血管舒缩控制

• 批准号: 6607418
• 负责人: THOMAS Joseph MCDONALD
• 金额: $ 27.83万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6607418
• 关键词: developmental neurobiology; embryo /fetus surgery; embryology; glucocorticoids; hypertension; paraventricular nucleus; sheep; sympathetic nervous system; vasomotion

DESCRIPTION: (Adapted from the Investigator's Abstract): Stereotaxic neurosurgical techniques and baroreflex challenges will be employed in the chronically-instrumented fetal sheep to surgically disconnect the PVN to evaluate the extent to which and the mechanisms by which the late gestation fetal sheep PVN: (1) modifies normal development of brainstem and sympathetic preganglionic neuron regulation of peripheral vascular tone; and (2) is a site for production of glucocorticoid-induced hypertension.

描述：（改编自研究者摘要）：立体定位 神经外科技术和压力反射的挑战将在 用长期内固定的胎羊手术断开PVN， 评估妊娠晚期妊娠的程度和机制， 胎羊PVN：（1）改变脑干和交感神经的正常发育 神经节前神经元调节外周血管张力;（2）是一个位点 糖皮质激素诱发的高血压