Vitamin K: vascular calcification and age-related bone *

描述（由申请人提供）： 维生素K可能在血管钙化的发病机制中发挥作用， 以及与年龄相关的骨质流失。流行病学证据表明 维生素K依赖蛋白、基质玻璃蛋白（MGP） 和血管钙化。维生素K营养的生化标志物 除了低骨量外，还与血管钙化有关。 维生素K的膳食摄入量很低。然而，目前尚不清楚这些 维生素K营养标志物是普遍营养不良的指标， 在这些研究中。此外，长期服用维生素K 补充剂对血管钙化的影响尚未研究。中 一项为期3年、双盲、安慰剂对照研究的辅助研究， 补充维生素K对骨密度和骨密度的影响 周转，我们建议研究维生素K补充剂（500 g/d）对450名男性和女性血管钙化进展的影响， 60-80岁，已经在监测骨质流失。我们将测量 使用电子束计算机断层摄影术的血管钙化 （EBCT）在开始和结束3年的维生素K补充。 此外，我们将在第1、6、12、24和25天测量血清MGP和血脂。 36个月的维生素K补充。其他协变量， 作为资助研究的一部分，在研究过程中收集的数据包括 维生素K、维生素D和钙的生化标志物，骨标志物 营业额，髋部骨密度，年龄，人体测量数据，体力活动，饮食 摄入量、药物使用和吸烟。拟议的辅助试验提供了 确定维生素K补充剂是否会减少 老年男性和女性血管钙化的进展。

DESCRIPTION (provided by applicant): Vitamin K may play a role in the pathogenesis of vascular calcification, as well as age-related bone loss. Epidemiological evidence has shown associations between the vitamin K-dependent protein, Matrix Gla Protein (MGP) and vascular calcification. Biochemical markers of vitamin K nutrition have been associated with vascular calcification, in addition to low bone mass. Usual dietary intakes of vitamin K are low. However, it is not known if these markers of vitamin K nutrition are indicators of generalized poor nutritional status in these studies. Furthermore, the impact of long-term vitamin K supplementation on vascular calcification has not been examined. In an ancillary study to a funded 3-year, double-blind, placebo controlled study on the effect of vitamin K supplementation on bone mineral density (BMD) and bone turnover, we propose to study the effect of vitamin K supplementation (500 g/d) on the progression of vascular calcification in 450 men and women, aged 60-80 years, who are already being monitored for bone loss. We will measure vascular calcification using electron beam computed tomography (EBCT) at the beginning and the end of 3 years of vitamin K supplementation. In addition, we will measure serum MGP and plasma lipids at 1, 6, 12, 24, and 36 months of vitamin K supplementation. Other covariates that will be collected through the course of the study as part of the funded study, include biochemical markers of vitamin K, vitamin D and calcium, markers of bone turnover, BMD of the hip, age, anthropometric data, physical activity, dietary intakes, medication use, and smoking. The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women.