FASEB SRC on Molecular, Structural & Clinical Aspects of Vitamin K & Vitamin K-dependent Proteins

FASEB SRC 关于分子、结构

• 批准号: 8907590
• 负责人: SARAH Louise BOOTH
• 金额: $ 2.32万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8907590
• 关键词: Address; Aging; Anticoagulants; Anticoagulation; Area; Basic Science; Biochemistry; Biology; Blood Coagulation Disorders; Blood coagulation; Cardiovascular Diseases; Cellular biology; Chairperson; Chronic Kidney Failure; Clinical; Clinical Management; Clinical Research; Coagulation Process; Coenzymes; Collaborations; Communities; Degenerative polyarthritis; Development; Diabetes Mellitus; Dietary Factors; Discipline; Endocrine; Endocrinology; Ensure; Enzymes; Extrahepatic; Feedback; Future; Generations; Genetic; Genetic Polymorphism; Goals; Health; Hematology; Hemostatic function; High Prevalence; Individual; Inflammation; Inflammatory; International; Knowledge; Light; Link; Metabolic; Metabolism; Mission; Molecular; Nature; Nephrology; Obesity; Oral; Osteocalcin; Oxidative Stress; Pathway interactions; Patients; Pharmacogenomics; Physiological; Population; Prevention; Process; Protein C; Protein S; Proteins; Public Health; Regulation; Renal function; Research; Research Personnel; Role; Safety; Scientific Societies; Scientist; Thrombin; Time; Tissues; Translational Research; Vascular calcification; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin; base; bone; burden of illness; calcification; clinical application; experience; innovation; interdisciplinary approach; interest; matrix Gla protein; meetings; multidisciplinary; novel; nutrition; posters; prevent; programs; public health relevance; response; symposium; vitamin K epoxide reductase

 DESCRIPTION (provided by applicant): Vitamin K (VK) was discovered for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation. In the past, the cohesiveness of the VK field was largely maintained by the focus on hemostasis. However, the field of VK now extends beyond this focus and is actively being studied across highly diverse disciplines by investigators new to the VK field. Scientific interactions have become increasingly challenging because VK biology is no longer represented by a single scientific society. The 2015 FASEB Summer Conference on "Molecular, Structural & Clinical Aspects of VK & VK-Dependent Proteins" is significant to the field because it is the only national and/or international conference dedicated to the study of VK biology. The overall objective of this conference is to provide a forum for the exchange of new knowledge about VK that spans from basic research to a wide variety of clinical applications. In recognition of this unique and highly disciplinary theme, our overarching conference goals are to: (1) Feature recognized multidisciplinary experts covering topics related to VK; (2) Discuss major advances in the field among young and experienced investigators, including those who are based in disciplines not traditionally associated with the VK community; and (3) Ensure a continued influx of new ideas and new investigators. To achieve this, we have created a program composed of many speakers who will be interacting with the VK community for the first time. We have also incorporated multiple opportunities for the interaction of graduate and post-graduate trainees and junior scientists with established investigators to promote a new cadre of investigators in the field of VK. The scientific problems to be discussed at the 2015 conference reflect this translational nature of VK biology: (1) Evaluate current research on VK metabolism and its unique actions both from basic and clinical research perspectives; (2) Advance our current knowledge on the use of warfarin, direct oral anticoagulants (DOACs), and pharmacogenomic information to develop optimal treatment and prevention of associated coagulopathy; (3) Evaluate new developments that suggest emerging roles for VK-dependent proteins in managing clinical conditions such as CVD, osteoarthritis, and chronic kidney disease; and (4) Advance the understanding VK epoxide reductase (VKOR). This conference is innovative because it will provide discussion on new linkages and roles of VK by drawing on the multi-disciplinary expertise of confirmed chairpersons and speakers in the basic science and clinical fields of cell biology, biochemistry, endocrinology, nephrology, hematology and nutrition, and will facilitate new collaborations and areas of novel research.

 描述（由申请方提供）：维生素K（VK）因其止血作用而被发现，历史上的要求是基于正常凝血所需的量。在过去，VK领域的凝聚力主要是通过对止血的关注来维持的。然而，VK领域现在已经超出了这一重点，并且正在由VK领域的新研究人员积极研究高度多样化的学科。科学互动变得越来越具有挑战性，因为VK生物学不再由一个单一的科学社会代表。2015年FASEB夏季会议“VK和VK依赖蛋白质的分子，结构和临床方面”对该领域具有重要意义，因为它是唯一致力于VK生物学研究的国家和/或国际会议。本次会议的总体目标是提供一个论坛，交流有关VK的新知识，从基础研究到各种临床应用。在认识到这一独特的和高度学科化的主题，我们的总体会议目标是：（1）功能公认的多学科专家，涵盖与VK相关的主题;（2）讨论在年轻和经验丰富的研究人员，包括那些谁是基于传统上不与VK社区相关的学科领域的重大进展;和（3）确保新的想法和新的研究人员的持续涌入。为了实现这一目标，我们创建了一个由许多演讲者组成的计划，他们将首次与VK社区进行互动。我们还为毕业生和研究生学员以及初级科学家与既定调查人员的互动提供了多种机会，以促进VK领域新的调查人员队伍。在2015年会议上讨论的科学问题反映了VK生物学的这种转化性质：（1）从基础和临床研究的角度评估目前对VK代谢及其独特作用的研究;（2）推进我们目前对华法林使用的知识，直接口服抗凝剂（DOAC）和药物基因组学信息，以开发相关凝血病的最佳治疗和预防;（3）评估新的发展，表明VK依赖性蛋白在管理临床疾病，如CVD，骨关节炎和慢性肾脏疾病中的新作用;（4）推进对VK环氧化物还原酶（VKOR）的理解。本次会议是创新的，因为它将提供关于新的联系和VK的作用的讨论，通过借鉴确认的主席和发言者在细胞生物学，生物化学，内分泌学，肾脏学，血液学和营养学的基础科学和临床领域的多学科专业知识，并将 促进新的合作和新的研究领域。