FASEB SRC on Molecular, Structural & Clinical Aspects of Vitamin K & Vitamin K-dependent Proteins

FASEB SRC 关于分子、结构

• 批准号: 8907590
• 负责人: SARAH Louise BOOTH
• 金额: $ 2.32万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8907590
• 关键词: Address; Aging; Anticoagulants; Anticoagulation; Area; Basic Science; Biochemistry; Biology; Blood Coagulation Disorders; Blood coagulation; Cardiovascular Diseases; Cellular biology; Chairperson; Chronic Kidney Failure; Clinical; Clinical Management; Clinical Research; Coagulation Process; Coenzymes; Collaborations; Communities; Degenerative polyarthritis; Development; Diabetes Mellitus; Dietary Factors; Discipline; Endocrine; Endocrinology; Ensure; Enzymes; Extrahepatic; Feedback; Future; Generations; Genetic; Genetic Polymorphism; Goals; Health; Hematology; Hemostatic function; High Prevalence; Individual; Inflammation; Inflammatory; International; Knowledge; Light; Link; Metabolic; Metabolism; Mission; Molecular; Nature; Nephrology; Obesity; Oral; Osteocalcin; Oxidative Stress; Pathway interactions; Patients; Pharmacogenomics; Physiological; Population; Prevention; Process; Protein C; Protein S; Proteins; Public Health; Regulation; Renal function; Research; Research Personnel; Role; Safety; Scientific Societies; Scientist; Thrombin; Time; Tissues; Translational Research; Vascular calcification; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin; base; bone; burden of illness; calcification; clinical application; experience; innovation; interdisciplinary approach; interest; matrix Gla protein; meetings; multidisciplinary; novel; nutrition; posters; prevent; programs; public health relevance; response; symposium; vitamin K epoxide reductase

 DESCRIPTION (provided by applicant): Vitamin K (VK) was discovered for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation. In the past, the cohesiveness of the VK field was largely maintained by the focus on hemostasis. However, the field of VK now extends beyond this focus and is actively being studied across highly diverse disciplines by investigators new to the VK field. Scientific interactions have become increasingly challenging because VK biology is no longer represented by a single scientific society. The 2015 FASEB Summer Conference on "Molecular, Structural & Clinical Aspects of VK & VK-Dependent Proteins" is significant to the field because it is the only national and/or international conference dedicated to the study of VK biology. The overall objective of this conference is to provide a forum for the exchange of new knowledge about VK that spans from basic research to a wide variety of clinical applications. In recognition of this unique and highly disciplinary theme, our overarching conference goals are to: (1) Feature recognized multidisciplinary experts covering topics related to VK; (2) Discuss major advances in the field among young and experienced investigators, including those who are based in disciplines not traditionally associated with the VK community; and (3) Ensure a continued influx of new ideas and new investigators. To achieve this, we have created a program composed of many speakers who will be interacting with the VK community for the first time. We have also incorporated multiple opportunities for the interaction of graduate and post-graduate trainees and junior scientists with established investigators to promote a new cadre of investigators in the field of VK. The scientific problems to be discussed at the 2015 conference reflect this translational nature of VK biology: (1) Evaluate current research on VK metabolism and its unique actions both from basic and clinical research perspectives; (2) Advance our current knowledge on the use of warfarin, direct oral anticoagulants (DOACs), and pharmacogenomic information to develop optimal treatment and prevention of associated coagulopathy; (3) Evaluate new developments that suggest emerging roles for VK-dependent proteins in managing clinical conditions such as CVD, osteoarthritis, and chronic kidney disease; and (4) Advance the understanding VK epoxide reductase (VKOR). This conference is innovative because it will provide discussion on new linkages and roles of VK by drawing on the multi-disciplinary expertise of confirmed chairpersons and speakers in the basic science and clinical fields of cell biology, biochemistry, endocrinology, nephrology, hematology and nutrition, and will facilitate new collaborations and areas of novel research.

 描述（由适用提供）：维生素K（VK）是因为其在止血中的作用而发现的，并且在历史上是基于正常血液凝结所需的数量。过去，VK场的凝聚力在很大程度上是通过对止血的关注来维持的。但是，VK的领域现在扩展到了这一重点，并且正在积极研究VK Field的调查人员在高度潜水的学科中进行研究。科学互动变得越来越挑战，因为VK生物学不再由一个科学社会代表。 2015年FASEB夏季会议在“ VK＆VK依赖性蛋白质的分子，结构和临床方面”对该领域很重要，因为它是唯一致力于研究VK生物学研究的国家和/或国际会议。这次会议的总体目的是提供一个论坛，以交换有关VK的新知识，该知识从基础研究到各种临床应用。为了表彰这个独特且高学科的主题，我们的总体会议目标是：（1）功能公认的多学科专家，涵盖与VK相关的主题； （2）讨论年轻和经验丰富的调查人员中该领域的重大进展，包括基于传统上与VK社区相关的学科的研究人员； （3）确保持续涌入新的想法和新调查人员。为了实现这一目标，我们创建了一个由许多演讲者组成的计划，这些计划将首次与VK社区互动。我们还为研究生和研究生学员以及初级科学家与已建立的研究人员的互动融合了多个机会，以促进VK领域的新调查人员干部。在2015年会议上要讨论的科学问题反映了VK生物学的这种翻译性质：（1）从基本和临床研究的角度评估当前对VK代谢及其独特行动的研究； （2）我们当前有关使用华法林，直接口服抗凝剂（DOAC）和药物基因组学信息的知识，以开发最佳治疗和预防相关的凝血病； （3）评估新的发展，这些发展表明VK依赖性蛋白在管理CVD，骨关节炎和慢性肾脏疾病等临床状况中的新兴作用； （4）提高理解VK环氧还原（VKOR）。这次会议具有创新性，因为它将通过借鉴确认的主席和演讲者的多学科专业知识，在细胞生物学，生物化学，内分泌学，肾脏学，血液学和营养以及将会提供有关VK的新联系和角色的讨论。 促进新研究的新合作和领域。