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The Human Parkin Promoter and NACP-Rep 1 Enhancer

The Human Parkin Promoter and NACP-Rep 1 Enhancer
Human Parkin 启动子和 NACP-Rep 1 增强子
批准号：
6551987
负责人：
Andrew B West
金额：
$3.08万
依托单位：
MAYO CLINIC JACKSONVILLE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
未结题
起止时间：
2002-09-01 至
来源：
https://reporter.nih.gov/project-details/6551987
关键词：
DNA binding protein DNA footprinting Parkinson's disease alpha synuclein autosomal dominant trait binding sites disease /disorder onset gel mobility shift assay gene mutation genetic enhancer element genetic promoter element genetic regulation genetic transcription neurogenetics polymerase chain reaction predoctoral investigator tissue /cell culture

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DESCRIPTION (provided by applicant): Mutations in the alpha-synuclein gene (NACP) cause an autosomal-dominant Parkinson's disease (PD), while mutations in the parkin gene cause an autosomal-recessive juvenile and early-onset PD. Parkin mutations are prevalent and the principle cause of early-onset PD, and a-synuclein haplotypes have been associated with idiopathic PD. Understanding the regulation of these genes should help characterize their normal cellular function and perhaps provide clues as to the pathogenesis of PD. The research aims proposed study the transcriptional regulation of parkin and alpha-synuclein, and will determine whether these regulatory regions are associated, functionally or genetically, with Parkinson's disease.
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Project 3: LRRK2 mediated macrophage responses in PD
Project 3: LRRK2 mediated macrophage responses in PD
Mechanisms of LRRK2 Mediated Neurotoxicity
  • 批准号：
    9883049
  • 项目类别：
  • 资助金额：
    $35.0万
  • 财政年份：
    2018
  • 负责人：
    Andrew B West
  • 依托单位：
    DUKE UNIVERSITY
Mechanisms of LRRK2 Mediated Neurotoxicity
  • 批准号：
    10117999
  • 项目类别：
  • 资助金额：
    $40.25万
  • 财政年份：
    2018
  • 负责人：
    Andrew B West
  • 依托单位：
    DUKE UNIVERSITY
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