HCMV GB 在极化上皮 CACO 2 细胞中的贩运-猫眼课题宝

HCMV GB 在极化上皮 CACO 2 细胞中的贩运

批准号：

6510192

负责人：

MICHAEL ARTHUR JARVIS

金额：

$5.01万

依托单位：

OREGON HEALTH & SCIENCE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

未结题

起止时间：

2002-03-01 至

来源：

https://reporter.nih.gov/project-details/6510192

关键词：

Herpesviridae disease apical membrane basolateral membrane cellular polarity cytomegalovirus endoplasmic reticulum epithelium glycoproteins host organism interaction intracellular transport microorganism culture protein transport tissue /cell culture virus protein virus replication

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英文摘要

Bone marrow transplantation is an effective treatment for leukemia. However, the iatrogenic immunosuppression leaves the patient susceptible to disease as a result of human cytomegalovirus (HCMV) infection. In vivo, fibroblastic, neuronal and epithelial cells are infected by HCMV. In these cell types, understanding the mechanisms by which the essential viral protein complex gB traffics to the site(s) of infectious virus production may be important for the generation of new anti-viral compounds. The aim of this proposal is to investigate the trafficking of mechanisms of gB in an epithelial line (Caco-2).

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Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication.

人巨细胞病毒糖蛋白 B (gB) 在酸性簇酪蛋白激酶 2 位点 (Ser900) 的磷酸化是 gB 定位到跨高尔基体网络和有效病毒复制所必需的。

DOI： 10.1128/jvi.78.1.285-293.2004

发表时间： 2004

期刊：

Journal of virology

影响因子： 5.4

作者：